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Titolo:
Procalcitonin behaves as a fast responding acute phase protein in vivo andin vitro
Autore:
Nijsten, MWN; Olinga, P; The, TH; de Vries, EGE; Koops, HS; Groothuis, GMM; Limburg, PC; ten Duis, HJ; Moshage, H; Hoekstra, HJ; Bijzet, J; Zwaveling, JH;
Indirizzi:
Univ Groningen Hosp, Dept Surg, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Clin Immunol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Med Oncol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Surg Oncol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Rheumatol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Gastroenterol & Hepatol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen, Groningen Inst Drug Studies, Dept Pharmacokinet & Drug Delivery, Univ Ctr Pharm, Groningen, Netherlands Univ Groningen Groningen Netherlands Ctr Pharm, Groningen, Netherlands
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 2, volume: 28, anno: 2000,
pagine: 458 - 461
SICI:
0090-3493(200002)28:2<458:PBAAFR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED LIMB PERFUSION; INTERFERON-GAMMA; LIVER SLICES; NECROSIS; SEPSIS; INFECTION; MELPHALAN; TISSUE; ALPHA;
Keywords:
acute phase protein; C-reactive protein; serum amyloid protein A; calcitonin; endotoxins; interleukin-6; tumor necrosis factor; infection; neoplasms; sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Nijsten, MWN Univ Groningen Hosp, Dept Surg, POB 30-001, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp POB 30-001 Groningen Netherlands NL-9700 RB
Citazione:
M.W.N. Nijsten et al., "Procalcitonin behaves as a fast responding acute phase protein in vivo andin vitro", CRIT CARE M, 28(2), 2000, pp. 458-461

Abstract

Objectives: Procalcitonin (PCT) is a 13 kD protein of which plasma concentrations are strongly increased in inflammatory states, PCT concentrations are claimed to have a more powerful discriminatory value for bacterial infection than the acute phase proteins serum amyloid A (SAA) or C-reactive protein (CRP), The source of production and its mechanism of induction are unknown, We investigated the inducibility of PCT both in vivo and in vitro and compared the behavior of PCT with those of SAA and CRP,Design: A prospective descriptive patient sample study and a controlled liver tissue culture study. Setting: A university hospital,Patients: Cancer patients who were treated with human tumor necrosis factor-alpha (rhTNF-alpha; 5 patients) or interleukin-6 (rhIL-6; 7 patients),Measurements and Main Results: Serial serum samples were collected for analysis of concentrations of PCT, SAA, and GRP, In the TNF-alpha group, frequent sampling was performed on the first day to allow analysis of initial responses, In a human liver slice model, the release of PCT, SAA, and CRP wasmeasured on induction with rhTNF-alpha and rhIL-6 for 24 hrs, We found that PCT displayed acute phase reactant behavior in vivo after administration of both rhTNF-alpha and rhIL-6. after rhTNF-alpha-administration, PCT reached half-maximal concentrations within 8 hrs, 12 hrs earlier than either SAAor GRP did. PCT, SAA, and CRP were produced in detectable quantities by liver tissue in vitro, PCT production by liver slices was enhanced after stimulation with rhTNF-alpha or rhIL-6; SAA and CRP concentrations were elevated after stimulation with rhTNF-alpha. Conclusions: We found that PCT and acute phase proteins such as CRP are induced by similar pathways, The liver appears to be a major source of PCT production, Thus, PCT may be considered an acute phase protein. The differentkinetics of PCT, rather than a fundamentally different afferent pathway, may explain its putative diagnostic potential to discriminate bacterial infection from other causes of inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:42:56