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Titolo:
Suppression of endogenous insulin secretion by exogenous insulin in patients with insulinoma
Autore:
Kim, CH; Park, JY; Shong, YK; Hong, SK; Kim, GS; Lee, KU;
Indirizzi:
Univ Ulsan, Dept Internal Med, Div Endocrinol & Metab, Asan Med Ctr,Coll Med, Seoul 138600, South Korea Univ Ulsan Seoul South Korea 138600 ,Coll Med, Seoul 138600, South Korea
Titolo Testata:
CLINICAL ENDOCRINOLOGY
fascicolo: 1, volume: 52, anno: 2000,
pagine: 87 - 92
SICI:
0300-0664(200001)52:1<87:SOEISB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE CLAMP TECHNIQUE; HYPERINSULINEMIA; HYPOGLYCEMIA; INHIBITION; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, KU Univ Ulsan, Dept Internal Med, Div Endocrinol & Metab, Asan Med Ctr,Coll Med, Song Pa POB 145, Seoul 138600, South Korea Univ Ulsan Song Pa POB 145 Seoul South Korea 138600 , South Korea
Citazione:
C.H. Kim et al., "Suppression of endogenous insulin secretion by exogenous insulin in patients with insulinoma", CLIN ENDOCR, 52(1), 2000, pp. 87-92

Abstract

OBJECTIVE Previous studies have demonstrated that endogenous insulin secretion is not suppressed by exogenous insulin in patients with insulinoma. Inthis study we examined whether insulin secretion in insulinoma patients issuppressed by exogenous insulin during hypoglycaemia. SUBJECTS AND METHODS Sixteen insulinoma patients (5 men and 11 women) and 10 normal subjects were studied. Hyperinsulinaemic glucose clamp studies were performed at both euglycaemia (4.5 mmol/l glucose) and hypoglycaemia (2.5 mmol/l glucose). RESULTS In normal subjects, plasma C-peptide levels were suppressed by 66%during the euglycaemic hyperinsulinaemic clamps (P < 0.01). In contrast, in insulinoma patients, plasma C-peptide levels increased by 25% during the clamps (P < 0.05). In the hypoglycaemic hyperinsulinaemic clamps, plasma C-peptide levels were nearly completely (91%) suppressed in normal subjects and partially (39%) suppressed in patients with insulinoma (P < 0.01). The decrease in C-peptide levels during the hypoglycaemic clamps was > 30% in 12(75%) of 16 insulinoma patients and > 50% in 8 (50%) patients. CONCLUSIONS This study demonstrated that in patients with insulinoma, insulin secretion was not suppressed by exogenous insulin during euglycaemia but was suppressed during hypoglycaemia, although the degree of suppression was less than that in normal subjects. Our results suggest that the feedbackregulation of insulin secretion by exogenous insulin is partially retainedin patients with insulinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:20:30