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Titolo:
Significance of neuron-specific enolase levels before and during therapy for small cell lung cancer
Autore:
Bonner, JA; Sloan, JA; Rowland, KM; Klee, GG; Kugler, JW; Mailliard, JA; Wiesenfeld, M; Krook, JE; Maksymiuk, AW; Shaw, EG; Marks, RS; Perez, EA;
Indirizzi:
Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Fdn, Rochester, MN 55905 USA Carle Canc Ctr, CCOP, Urbana, IL 61801 USA Carle Canc Ctr Urbana IL USA 61801 e Canc Ctr, CCOP, Urbana, IL 61801 USA Illinois Oncol Res Assoc, CCOP, Peoria, IL 61602 USA Illinois Oncol Res Assoc Peoria IL USA 61602 , CCOP, Peoria, IL 61602 USA Univ Nebraska, Med Ctr & Associates, Creighton Univ, Nebraska Oncol Grp, Omaha, NE 68131 USA Univ Nebraska Omaha NE USA 68131 Nebraska Oncol Grp, Omaha, NE 68131 USA Cedar Rapids Oncol Project, CCOP, Cedar Rapids, IA 52403 USA Cedar Rapids Oncol Project Cedar Rapids IA USA 52403 Rapids, IA 52403 USA Duluth CCOP, Duluth, MN 55805 USA Duluth CCOP Duluth MN USA 55805Duluth CCOP, Duluth, MN 55805 USA Saskatoon Canc Ctr, Saskatoon, SK S7N 4H4, Canada Saskatoon Canc Ctr Saskatoon SK Canada S7N 4H4 katoon, SK S7N 4H4, Canada Mayo Clin Jacksonville, Jacksonville, FL 32224 USA Mayo Clin JacksonvilleJacksonville FL USA 32224 cksonville, FL 32224 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 2, volume: 6, anno: 2000,
pagine: 597 - 601
SICI:
1078-0432(200002)6:2<597:SONELB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE; TUMOR-MARKER; S-NSE; CARCINOMA; SCLC; CEA; SCC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bonner, JA Univ Alabama, Dept Radiat Oncol, 619 South 19th St,WTI105, Birmingham, AL 35233 USA Univ Alabama 619 South 19th St,WTI105 Birmingham AL USA 35233 A
Citazione:
J.A. Bonner et al., "Significance of neuron-specific enolase levels before and during therapy for small cell lung cancer", CLIN CANC R, 6(2), 2000, pp. 597-601

Abstract

The level of serum neuron-specific enolase (NSE) has been implicated as a prognostic factor for patients with small cell lung cancer (SCLC). a prospective evaluation was undertaken to assess the prognostic significance of pretreatment NSE and treatment-induced minimum NSE values in patients with SCLC, Patients from two Phase III North Central Cancer Treatment Group trials[one for patients with extensive stage SCLC and one for patients with limited stage SCLC] were asked to enter this laboratory correlational trial. Both trials included treatment with four to six cycles of etoposide and cisplatin, and 121 patients (71 extensive stage SCLC and 50 limited stage SCLC) were entered into the present study of NSE, Pretreatment NSE values and treatment-induced minimum NSE values were independent predictors of time to progression and survival in multivariate analysis. Hazard rate modeling allowed the formulation of specific relationships of NSE to time to progression and survival. Pretreatment NSE levels inversely correlated with time to progression and survival in these patients with SCLC, Pretreatment NSE accounted for 28% of the variance in survival, Both pretreatment NSE and treatment-induced minimum NSE were independent prognostic predictors of time to progression and survival.

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Documento generato il 05/04/20 alle ore 03:43:42