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Titolo:
Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
Autore:
Koukourakis, MI; Giatromanolaki, A; Fountzilas, G; Sivridis, E; Gatter, KC; Harris, AL;
Indirizzi:
Univ Thessalia, Sch Med, Tumour & Angiogenesis Res Grp, Dept Radiotherapy & Oncol, Larissa 41222, Greece Univ Thessalia Larissa Greece 41222 erapy & Oncol, Larissa 41222, Greece Democritus Univ Thrace, Dept Pathol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Aristotelian Univ Salonika, AHEPA Hosp, Hellen Cooperat Oncol Grp, Dept Med Oncol, Salonika 54006, Greece Aristotelian Univ Salonika Salonika Greece 54006 Salonika 54006, Greece Oxford Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ ci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp, Imperial Canc Res Fund Med Oncol Unit, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ it, Oxford OX3 7LJ, England
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 2, volume: 6, anno: 2000,
pagine: 381 - 389
SICI:
1078-0432(200002)6:2<381:ATPARO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; FRACTIONATED-IRRADIATION; TREATMENT TIME; EXPRESSION; CARCINOMA; REPOPULATION; RADIOTHERAPY; TUMORS; IMPACT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Koukourakis, MI Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
M.I. Koukourakis et al., "Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy", CLIN CANC R, 6(2), 2000, pp. 381-389

Abstract

Thymidine phosphorylase (TP), an enzyme involved in the thymidine synthesis and degradation, has been shown to promote tumor angiogenesis, Both TP expression and tumor vascularization are putative postoperative prognostic markers of cancer. Because of its bifunctional role, TP may have interactionswith cytotoxic drugs or radiation via pathways requiring thymidine or prodrug activation. The microvessel score and TP expression were examined immunohistochemically on paraffin-embedded bioptical material from 94 locally advanced squamous cell head and neck carcinomas. All patients were treated with conventionally fractionated radiotherapy combined with induction (platinum- and 5-fluoronracil-based) or concurrent platinum chemotherapy. The follow-up of patients ranged from 6 to 108 months (median, 48 months). Nuclear TP expression was significantly associated with increased microvessel score(P < 0.0001, r = 0.45). A low percentage of cancer cells with nuclear TP expression in pretreatment biopsies was associated with a high rate of CR after combined chemoradiotherapy (P = 0.006) and induction chemotherapy (0.01). A better local relapse-free and overall survival was also observed in these patients (P = 0.001 and P = 0.0005, respectively). Biospies on the day after the delivery of 20 Gy of conventionally fractionated radiotherapy showed residual cancer cell nests, frequently of high vascularization and of intense nuclear TP reactivity, It is concluded that thymidine phosphorylase is associated with angiogenesis, with resistance to radiotherapy and cytotoxic therapy, and with poorer survival in squamous cell head and neck cancer, A strong rationale is provided for subsequent clinical trials of concurrent radiotherapy and chemotherapy with antiangiogenic agents or with specific TP inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:02:58