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Titolo:
Successful surgical removal of occult metastases of medullary thyroid carcinoma recurrences with the help of immunoscintigraphy and radioimmunoguidedsurgery
Autore:
de Labriolle-Vaylet, C; Cattan, P; Sarfati, E; Wioland, M; Billotey, C; Brocheriou, C; Rouvier, E; de Roquancourt, A; Rostene, W; Askienazy, S; Barbet, J; Milhaud, G; Gruaz-Guyon, A;
Indirizzi:
INSERM U339, Fac Med St Antoine, F-75012 Paris, France INSERM U339 ParisFrance F-75012 c Med St Antoine, F-75012 Paris, France Hop St Antoine, INSERM U339, F-75012 Paris, France Hop St Antoine Paris France F-75012 , INSERM U339, F-75012 Paris, France Hop St Antoine, Nucl Med Serv, F-75012 Paris, France Hop St Antoine Paris France F-75012 Nucl Med Serv, F-75012 Paris, France Hop St Antoine, Fac Med, F-75012 Paris, France Hop St Antoine Paris France F-75012 oine, Fac Med, F-75012 Paris, France Hop St Louis, Serv Chirurg, Paris, France Hop St Louis Paris FranceHop St Louis, Serv Chirurg, Paris, France Hop St Louis, Nucl Med Serv, Paris, France Hop St Louis Paris FranceHop St Louis, Nucl Med Serv, Paris, France Hop St Louis, Serv Anatomopathol, Paris, France Hop St Louis Paris France p St Louis, Serv Anatomopathol, Paris, France Hop Trousseau, Nucl Med Serv, F-75571 Paris, France Hop Trousseau Paris France F-75571 Nucl Med Serv, F-75571 Paris, France Immunotech SA, F-13288 Marseille, France Immunotech SA Marseille France F-13288 ech SA, F-13288 Marseille, France
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 2, volume: 6, anno: 2000,
pagine: 363 - 371
SICI:
1078-0432(200002)6:2<363:SSROOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIUM-111-LABELED DTPA DIMER; BIVALENT HAPTEN; BISPECIFIC ANTIBODY; PLASMA CALCITONIN; OSTEOID OSTEOMAS; CANCER; MANAGEMENT; REOPERATION; PERSISTENT; RADIOIMMUNODETECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Gruaz-Guyon, A INSERM U339, Fac Med St Antoine, 27 Rue Chaligny, F-75012 Paris, France INSERM U339 27 Rue Chaligny Paris France F-75012 s, France
Citazione:
C. de Labriolle-Vaylet et al., "Successful surgical removal of occult metastases of medullary thyroid carcinoma recurrences with the help of immunoscintigraphy and radioimmunoguidedsurgery", CLIN CANC R, 6(2), 2000, pp. 363-371

Abstract

Patients with recurrent or metastatic medullary thyroid carcinoma (MTC) were referred for pretargeted immunoscintigraphy (Affinity Enhancement System; AES) and radioimmunoguided surgery (RIGS). Data collected from 13 patients establish that whole-body AES immunoscintigraphy revealed metastases <360mg and RIGS detected micrometastases (5-15 mg). All tissue samples removedby the surgeon were diagnosed by histology and immunohistochemistry of calcitonin to check the accuracy of IS and RIGS results. AES immunoscintigraphy is very sensitive, Of 34 metastases or recurrences detected, 22 had escaped physical examination or conventional imaging. The accuracy of RIGS was 86%, its sensitivity 75%, and its specificity was 90% (n: = 208), IS and RIGS detected occult tumors that would have escaped surgery, clearly demonstrating clinical benefit. Serum calcitonin (normal, 10 pg/ml) and carcino-embryonic antigen (normal, 5 ng/ml) of two patients were restored to normal. Inpatients whose tumors were discovered, progression of their disease was slowed, as evidenced by the large decrease in serum calcitonin and carcinoembryonic antigen, an important prognostic factor. Surgery was canceled in onecase where IS detected distant metastases out of surgical reach. Thus, AESimmunoscintigraphy and RIGS might be of valuable help for the surgical management of medullary thyroid carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:35:50