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Titolo:
Eosinophilic tracheobronchitis and airway cough hypersensitivity in chronic non-productive cough
Autore:
Fujimura, M; Ogawa, H; Yasui, M; Matsuda, T;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 3, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Ishikawa Ken Saiseikai Kanazawa Hosp, Div Pulm Med, Kanazawa, Ishikawa, Japan Ishikawa Ken Saiseikai Kanazawa Hosp Kanazawa Ishikawa Japan kawa, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 1, volume: 30, anno: 2000,
pagine: 41 - 47
SICI:
0954-7894(200001)30:1<41:ETAACH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC NONPRODUCTIVE COUGH; RECEPTOR SENSITIVITY; BRONCHIAL RESPONSIVENESS; BRONCHOALVEOLAR LAVAGE; INDUCED SPUTUM; ASTHMA; THERAPY; INFLAMMATION; REACTIVITY; CELLS;
Keywords:
airway cough sensitivity; atopic cough; bronchoalveolar lavage; chronic nonproductive cough; eosinophilic tracheobronchitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimura, M Kanazawa Univ, Sch Med, Dept Internal Med 3, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208641
Citazione:
M. Fujimura et al., "Eosinophilic tracheobronchitis and airway cough hypersensitivity in chronic non-productive cough", CLIN EXP AL, 30(1), 2000, pp. 41-47

Abstract

Background We have shown that some patients presenting with chronic bronchodilator-resistant non-productive cough have global atopic tendency and airway cough hypersensitivity without non-specific bronchial hyperresponsiveness, abbreviated as atopic cough. The cough is successfully treated with histamine H-1-antagonists and/or glucocorticoids. Objective This prospective study was conducted to elucidate the histological feature of atopic cough. Methods Tracheal and bronchial mucosa obtained by transbronchoscopic biopsy and bronchoalveolar lavage (BAL) cell component were studied with specialemphasis on eosinophils in eight non-smokers diagnosed with atopic cough, all of whom had increased sensitivity of cough response to inhaled capsaicin, normal lung function and bronchial responsiveness to methacholine and normal chest roentgenogram. Their cough completely resolved on histamine H-1-antagonists and/or glucocorticoids. Transbronchoscopic tracheal and bronchial biopsy and BAL were also performed in healthy non-smokers as a control. Results A small number of eosinophils was detected in subepithelium of trachea in six of seven patients and in subepithelium of bronchi in seven of eight cough patients. The numbers of eosinophils in subepithelium of tracheaand bronchi were significantly increased in the patients compared with control subjects. There was no BAL eosinophilia in any patients. Conclusion It is concluded that eosinophilic tracheobronchitis and cough hypersensitivity are pathological and physiological characteristics of atopic cough.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:38:09