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Titolo:
Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus
Autore:
Furlan, R; Porta, A; Costa, F; Tank, J; Baker, L; Schiavi, R; Robertson, D; Malliani, A; Mosqueda-Garcia, R;
Indirizzi:
Univ Milan, Osped L Sacco, Ctr Ric Cardiovasc, CNR,Unit Sincopi & DisturbiPostura, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 i & DisturbiPostura, I-20157 Milan, Italy Univ Milan, Ctr LITA Vialba, Milan, Italy Univ Milan Milan ItalyUniv Milan, Ctr LITA Vialba, Milan, Italy Vanderbilt Univ, Dept Med, Div Clin Pharmacol, Nashville, TN USA Vanderbilt Univ Nashville TN USA , Div Clin Pharmacol, Nashville, TN USA Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA Vanderbilt Univ Nashville TN USA 37235 omed Engn, Nashville, TN 37235 USA Clin Bavaria Kreischa, Kreischa, Germany Clin Bavaria Kreischa Kreischa Germany aria Kreischa, Kreischa, Germany Dupont Pharmaceut Co, Div Clin Pharmacol, Wilmington, DE USA Dupont Pharmaceut Co Wilmington DE USA lin Pharmacol, Wilmington, DE USA
Titolo Testata:
CIRCULATION
fascicolo: 8, volume: 101, anno: 2000,
pagine: 886 - 892
SICI:
0009-7322(20000229)101:8<886:OPISND>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POWER SPECTRAL-ANALYSIS; BLOOD-PRESSURE VARIABILITY; HEART-RATE-VARIABILITY; R-R INTERVAL; NERVE ACTIVITY; ARTERIAL-PRESSURE; AUTONOMIC FUNCTION; MEDIATED SYNCOPE; MAYER WAVES; HUMANS;
Keywords:
nervous system, autonomic; catecholamines; spectrum analysis; tilt-table test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Furlan, R Univ Milan, Osped L Sacco, Ctr Ric Cardiovasc, CNR,Unit Sincopi & DisturbiPostura, Via GB Grassi 74, I-20157 Milan, Italy Univ Milan Via GBGrassi 74 Milan Italy I-20157 57 Milan, Italy
Citazione:
R. Furlan et al., "Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus", CIRCULATION, 101(8), 2000, pp. 886-892

Abstract

Background-We tested the hypothesis that a common oscillatory pattern might characterize the rhythmic discharge of muscle sympathetic nerve activity (MSNA) and the spontaneous variability of heart rate and systolic arterial pressure (SAP) during a physiological increase of sympathetic activity induced by the head-up tilt maneuver. Methods and Results-Ten healthy subjects underwent continuous recordings of EGG, intra-arterial pressure, respiratory activity, central venous pressure. and MSNA, both in the recumbent position and during 75 degrees head-up tilt. Venous samplings for catecholamine assessment were obtained at rest and during the fifth minute of tilt, Spectrum and cross-spectrum analyses ofR-R interval, SAP, and MSNA variabilities and of respiratory activity provided the low (LF, 0.1 Hz) and high frequency (HF, 0.27 Hz) rhythmic components of each signal and assessed their linear relationships. Compared with the recumbent position. tilt reduced central venous pressure, but blood pressure was unchanged. Heart rate, MSNA, and plasma epinephrine and norepinephrine levels increased, suggesting a marked enhancement of overall sympathetic activity. During tilt, LFMSNA increased compared with the level in the supine position; this mirrored similar changes observed in the LF componentsof R-R interval and SAP variabilities, The increase of LFMSNA was proportional to the amount of the sympathetic discharge. The coupling between LF components of MSNA and R-R interval and SAP variabilities was enhanced duringtilt compared with rest. Conclusions-During the sympathetic activation induced by tilt, a similar oscillatory pattern based on an increased LF rhythmicity characterized the spontaneous variability of neural sympathetic discharge, R-R interval, and arterial pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:07:40