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Titolo:
A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities
Autore:
Li, LC; Chui, RM; Sasaki, M; Nakajima, K; Perinchery, G; Au, HC; Nojima, D; Carroll, P; Dahiya, R;
Indirizzi:
Vet Affairs Med Ctr, Dept Urol, San Francisco, CA 94121 USA Vet Affairs Med Ctr San Francisco CA USA 94121 an Francisco, CA 94121 USA Univ Calif San Francisco, San Francisco, CA 94121 USA Univ Calif San Francisco San Francisco CA USA 94121 ancisco, CA 94121 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 4, volume: 60, anno: 2000,
pagine: 873 - 876
SICI:
0008-5472(20000215)60:4<873:ASNPIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; PROSTATE-CANCER; CELL-LINES; HIGH-GRADE; EXPRESSION; CARCINOMA; INVASIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Dahiya, R Urol Res Ctr 112F, 4150 Clement St, San Francisco, CA 94121 USA Urol Res Ctr 112F 4150 Clement St San Francisco CA USA 94121 USA
Citazione:
L.C. Li et al., "A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities", CANCER RES, 60(4), 2000, pp. 873-876

Abstract

E-cadherin plays a critical role in many aspects of cell adhesion, epithelial development, and the establishment and maintenance of epithelial polarity. The loss of the adhesive function of E-cadherin is a critical step in the promotion of epithelial cells to a more malignant phenotype. We identified a C/A single nucleotide polymorphism at -160 from the transcriptional start site of the E-cadherin gene promoter. Transient transfection experiments showed that the A allele of this polymorphism decreased the transcriptional efficiency by 68% compared with the C allele (P < 0.001). Electrophoretic mobility shift and footprinting assays revealed that the C allele had a stronger transcriptional factor binding strength than the A allele, These results indicate that the -160 C/A polymorphism has a direct effect on E-cadherin gene transcriptional regulation. This allelic variation may be a potential genetic marker that can help identify those individuals at higher riskfor invasive/metastatic diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:13:40