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Titolo:
Utility of c-erbB-2 expression in tissue and sera of ovarian cancer patients
Autore:
Yazici, H; Dolapcioglu, K; Buyru, F; Dalay, N;
Indirizzi:
Istanbul Univ, Inst Oncol, Dept Basic Oncol, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 Oncol, TR-34390 Istanbul, Turkey Istanbul Univ, Fac Med, Dept Obstet & Gynaecol, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 naecol, TR-34390 Istanbul, Turkey
Titolo Testata:
CANCER INVESTIGATION
fascicolo: 2, volume: 18, anno: 2000,
pagine: 110 - 114
SICI:
0735-7907(2000)18:2<110:UOCEIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; PROGNOSTIC-SIGNIFICANCE; ONCOPROTEIN EXPRESSION; HER-2/NEU EXPRESSION; ONCOGENE; CARCINOMA; PROTOONCOGENE; OVEREXPRESSION; AMPLIFICATION; PRODUCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Dalay, N Istanbul Univ, Inst Oncol, Dept Basic Oncol, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 R-34390 Istanbul, Turkey
Citazione:
H. Yazici et al., "Utility of c-erbB-2 expression in tissue and sera of ovarian cancer patients", CANCER INV, 18(2), 2000, pp. 110-114

Abstract

In this study expression of the c-erbB-2 gene in tumors and healthy tissueof patients with ovarian cancer was investigated. Serum c-erbB-2 protein levels were also determined. Elevated serum values were observed in 45% of patients. c-erbB-2 protein levels in the armors were significantly higher than in healthy tissue. Overexpression of the protein was observed in 60% of patients. However no association was found between the clinical variables and tumor c-erbB-2 expression. This is the first study in the literature investigating the c-erbB-2 oncoprotein levels in the normal and tumor tissue. We conclude that the role of the c-erbB-2 gene in ovarian cancer warrants further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:35:15