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Titolo:
Demonstration of mRNA for five species of cytochrome P450 in human bone marrow, bone marrow-derived macrophages and human haemopoietic cell lines
Autore:
Hodges, VM; Molloy, GY; Wickramasinghe, SN;
Indirizzi:
Imperial Coll, Sch Med, Dept Haematol, London W2 1PG, England Imperial Coll London England W2 1PG ept Haematol, London W2 1PG, England
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 108, anno: 2000,
pagine: 151 - 156
SICI:
0007-1048(200001)108:1<151:DOMFFS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; DRUG-METABOLIZING-ENZYMES; APLASTIC-ANEMIA; POLYMORPHIC HYDROXYLATION; DEBRISOQUINE; ACTIVATION; DAMAGE; AGRANULOCYTOSIS; PATHOGENESIS; EXPRESSION;
Keywords:
cytochrome P450s; macrophages; bone marrow; haemopoietic cell lines; mRNA expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Wickramasinghe, SN Imperial Coll, Sch Med, Dept Haematol, St Marys Campus,Norfolk Pl, London W2 1PG, England Imperial Coll St Marys Campus,Norfolk PlLondon England W2 1PG
Citazione:
V.M. Hodges et al., "Demonstration of mRNA for five species of cytochrome P450 in human bone marrow, bone marrow-derived macrophages and human haemopoietic cell lines", BR J HAEM, 108(1), 2000, pp. 151-156

Abstract

The expression of mRNA for five cytochrome P450s (CYP1A1, 2A6/7, 2D6, 2E1 and 3A4) was studied in human bone marrow, bone-marrow-derived macrophages and blood monocyte-derived macrophages. Reverse transcriptase polymerase chain reaction (RT-PCR) detected expression of all Eve CYPs in each of these cell populations, All five CYPs were also expressed in the haemopoietic cell lines HL-60 and HEL and in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell lines. The data suggest that bone marrow macrophages and probably other bone marrow cell types are capable of metabolizing xenobiotics. This metabolic potential may play a role in the bone marrow damage induced by some drugs and chemicals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:23:08