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Titolo:
Selective destruction of nigrostriatal dopaminergic neurons does not alter[H-3]-ryanodine binding in rat striatum
Autore:
Noel, F; Geurts, M; Maloteaux, JM;
Indirizzi:
Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Farmacol Basica & Clin, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21941590 BCeiro, Brazil Univ Catholique Louvain, Fac Med, Pharmacol Lab, FARL 5410, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 2, volume: 33, anno: 2000,
pagine: 237 - 240
SICI:
0100-879X(200002)33:2<237:SDONDN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC MALIGNANT SYNDROME; RYANODINE RECEPTORS; H-3 GBR-12935; DANTROLENE; BRAIN; AUTORADIOGRAPHY; LOCALIZATION; HYPERTHERMIA; RELEASE; COMPLEX;
Keywords:
ryanodine; striatum; 6-hydroxydopamine; dopamine neurons; neuroleptic malignant syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Noel, F Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Farmacol Basica & Clin, BR-21941590 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21941590 BCazil
Citazione:
F. Noel et al., "Selective destruction of nigrostriatal dopaminergic neurons does not alter[H-3]-ryanodine binding in rat striatum", BRAZ J MED, 33(2), 2000, pp. 237-240

Abstract

Dopamine nigrostriatal neurons are important for motor control and may contain a particularly dense population of ryanodine receptors involved in thecontrol of dopamine release. To test this hypothesis, we used a classical model of unilateral selective lesion of these neurons in rats based on 6-hydroxydopamine (6-OHDA) injection into the substantia nigra. Binding of [H-3]-GBR 12935, used as a presynaptic marker since it labels specifically the dopamine uptake complex, was dramatically decreased by 83-100% in striatum homogenates after 6-OHDA lesion. On the contrary, no reduction of [H-3]-ryanodine binding was observed. The present data indicate that [H-3]-ryanodinebinding sites present in rat striatum are not preferentially localized in dopaminergic terminals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 05:37:10