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Titolo:
Cortical dysfunction in non-demented Parkinson's disease patients - A combined P-31-MRS and (18)FDG-PET study
Autore:
Hu, MTM; Taylor-Robinson, SD; Chaudhuri, KR; Bell, JD; Labbe, C; Cunningham, VJ; Koepp, MJ; Hammers, A; Morris, RG; Turjanski, N; Brooks, DJ;
Indirizzi:
Hammersmith Hosp, Imperial Coll, Sch Med, Med Res Council,Cyclotron Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN on Unit, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Sch Med, Robert Steiner MR Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN MR Unit, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Sch Med, Div Med, London W12 0NN, EnglandHammersmith Hosp London England W12 0NN Div Med, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Sch Med, Div Neurosci, London W12 0NN, England Hammersmith Hosp London England W12 0NN eurosci, London W12 0NN, England Guys Kings St Thomass Hosp Med Sch, Dept Neurosci, London, England Guys Kings St Thomass Hosp Med Sch London England osci, London, England Inst Psychiat, London, England Inst Psychiat London EnglandInst Psychiat, London, England Neurol Inst, London, England Neurol Inst London EnglandNeurol Inst, London, England
Titolo Testata:
BRAIN
, volume: 123, anno: 2000,
parte:, 2
pagine: 340 - 352
SICI:
0006-8950(200002)123:<340:CDINPD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; C-11 FLUMAZENIL-PET; ENERGY-METABOLISM; IN-VIVO; ALZHEIMERS-DISEASE; GLUCOSE-METABOLISM; NMR-SPECTROSCOPY; NORMATIVE DATA; BRAIN; INVIVO;
Keywords:
Parkinson's disease; magnetic resonance spectroscopy; PET; glucose; dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, MTM Hammersmith Hosp, Imperial Coll, Sch Med, Med Res Council,Cyclotron Unit, Du Cane Rd, London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN 2 0NN, England
Citazione:
M.T.M. Hu et al., "Cortical dysfunction in non-demented Parkinson's disease patients - A combined P-31-MRS and (18)FDG-PET study", BRAIN, 123, 2000, pp. 340-352

Abstract

Regional cerebral phosphorus-31 magnetic resonance spectroscopy (P-31-MRS)was performed in 10 nondemented Parkinson's disease patients and nine age-matched control subjects. Five of the patients undergoing P-31-MRS and fouradditional Parkinson's disease patients had cerebral 2-[F-18]fluoro-2-deoxy-D-glucose PET ((18)FDG-PET), the results of which were compared with those of eight age-matched control subjects. All Parkinson's disease patients underwent neuropsychological testing including performance and verbal subtests of the Wechsler Adult Intelligence Scale-Revised, Boston Naming Test, Controlled Oral World Association test (FAS Test) and California Learning Test to exclude clinical dementia. P-31 MR spectra from right and left temporo-parietal cortex, occipital cortex and a central voxel incorporating basal ganglia and brainstem were obtained. P-31 MR peak area ratios of signals from phosphomonoesters (PMEs), inorganic phosphate (P-i), phosphodiesters (PDEs), alpha-ATP, gamma-ATP and phosphocreatine (PCr) relative to beta-ATP were measured. Relative percentage peak areas of PMEs, P-i, PDEs, PCr, and alpha-, beta- and gamma-ATP signals were also measured with respect to the total P-31-MRS signal. Significant bilateral increases in the P-i/beta-ATP ratio were found in temporoparietal cortex (P = 0.002 right and P = 0.014 left cortex) for the non-demented Parkinson's disease patients compared with controls. In the right temporoparietal cortex, there was also a significant increase in the mean relative percentage P-i (P = 0.001). (18)FDG-PET revealed absolute bilateral reductions in glucose metabolism after partial volume effect correction in posterior parietal and temporal cortical grey matter(P < 0.01 and P < 0.05, respectively) for the Parkinson's disease group, using both volume of interest analysis and statistical parametric mapping. There were significant correlations between right temporoparietal P-i/beta-ATP ratios and estimated reductions in performance IQ (r = 0.96, P < 0.001). Left temporoparietal P-i/beta-ATP ratios correlated with full scale IQ andverbal IQ (r = - 0.82, P = 0.006, r = -0.86, P = 0.003, respectively), In summary, temporoparietal cortical hypometabolism was seen in non-demented Parkinson's disease patients with both P-31-MRS and (18)FDG-PET, suggesting that both glycolytic and oxidative pathways are impaired. This dysfunction may reflect either the presence of primary cortical pathology or deafferentation of striato-cortical projections. P-31-MRS and (18)FDG-PET may both provide useful predictors of future cognitive impairment in a subset of Parkinson's disease patients who go on to develop dementia.

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Documento generato il 13/07/20 alle ore 04:20:14