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Titolo:
Aminoglycoside antibiotics
Autore:
Forge, A; Schacht, J;
Indirizzi:
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ng Res Inst, Ann Arbor, MI 48109 USA Univ Coll London, Inst Laryngol & Otol, London WC1E 6BT, England Univ CollLondon London England WC1E 6BT Otol, London WC1E 6BT, England
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 1, volume: 5, anno: 2000,
pagine: 3 - 22
SICI:
1420-3030(200001/02)5:1<3:AA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC GENTAMICIN TREATMENT; COCHLEAR HAIR-CELLS; PIG INNER-EAR; OXYGEN-FREE-RADICALS; VESTIBULAR SENSORY EPITHELIA; GUINEA-PIG; IRON CHELATORS; IN-VIVO; NEURAL DEGENERATION; INDUCED OTOTOXICITY;
Keywords:
aminoglycosides; ototoxicity; mechanism of action; pharmacokinetics; prevention; reactive oxygen species;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
192
Recensione:
Indirizzi per estratti:
Indirizzo: Schacht, J Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109USA Univ Michigan 1301 E Ann St Ann Arbor MI USA 48109 MI 48109USA
Citazione:
A. Forge e J. Schacht, "Aminoglycoside antibiotics", AUDIOL NEUR, 5(1), 2000, pp. 3-22

Abstract

In the 50 years since their discovery, the aminoglycoside antibiotics haveseen unprecedented use, Discovered in the 1940s, they were the long-soughtremedy for tuberculosis and other serious bacterial infections. The side effects of renal and auditory toxicity, however, led to a decline of their use in most countries in the 1970s and 1980s, Nevertheless, today the aminoglycosides are still the most commonly used antibiotics worldwide thanks to the combination of their high efficacy with low cost. This review first summarizes the history, chemistry, antibacterial actions and acute side effects of the drugs. It then details the pathophysiology of aminoglycoside ototoxicity including experimental and clinical observations, risk factors and incidence, Pharmacokinetics, cellular actions and our current understanding of the underlying molecular mechanisms of ototoxicity are discussed at length. The review concludes with recent advances towards therapeutic intervention to prevent aminoglycoside ototoxicity. Copyright (C) 2000 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:12:12