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Titolo:
Amino acid losses during hemodialysis with polyacrylonitrile membranes: effect of intradialytic amino acid supplementation on plasma amino acid concentrations and nutritional variables in nondiabetic patients
Autore:
Navarro, JF; Mora, C; Leon, C; Martin-del Rio, R; Macia, ML; Gallego, E; Chahin, J; Mendez, ML; Rivero, A; Garcia, J;
Indirizzi:
Hosp Nuestra Senora Candelaria, Dept Nephrol, Santa Cruz De Tenerife 38010, Spain Hosp Nuestra Senora Candelaria Santa Cruz De Tenerife Spain 38010 Spain Hosp Nuestra Senora Candelaria, Dept Biochem, Santa Cruz De Tenerife 38010, Spain Hosp Nuestra Senora Candelaria Santa Cruz De Tenerife Spain 38010 Spain Hosp Nuestra Senora Candelaria, Res Unit, Santa Cruz De Tenerife 38010, Spain Hosp Nuestra Senora Candelaria Santa Cruz De Tenerife Spain 38010 Spain Hosp Ramon y Cajal, Res Unit, E-28034 Madrid, Spain Hosp Ramon y Cajal Madrid Spain E-28034 Res Unit, E-28034 Madrid, Spain
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 3, volume: 71, anno: 2000,
pagine: 765 - 773
SICI:
0002-9165(200003)71:3<765:AALDHW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; MAINTENANCE HEMODIALYSIS; PARENTERAL-NUTRITION; PROTEIN CATABOLISM; DIALYSIS PATIENTS; DEATH RISK; MORTALITY; MALNUTRITION; PREDICTORS; MORBIDITY;
Keywords:
albumin; amino acid losses; amino acid supplementation; malnutrition; nutritional status; end-stage renal disease; hemodialysis; men and women; Spain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Navarro, JF Hosp Nuestra Senora Candelaria, Dept Nephrol, Santa Cruz De Tenerife 38010, Spain Hosp Nuestra Senora Candelaria Santa Cruz De TenerifeSpain 38010
Citazione:
J.F. Navarro et al., "Amino acid losses during hemodialysis with polyacrylonitrile membranes: effect of intradialytic amino acid supplementation on plasma amino acid concentrations and nutritional variables in nondiabetic patients", AM J CLIN N, 71(3), 2000, pp. 765-773

Abstract

Background: Malnutrition is highly prevalent in hemodialysis patients. Amino acid (AA) losses during the dialysis procedure may! be a contributing factor. Objectives: The objectives of this study were I) to prospectively evaluateAA losses and their effect on plasma AA concentrations during dialysis with polyacrylonitrile at baseline and after administration of AAs by intradialysis and 2) to investigate the effects of intradialytic AA supplementationon nutritional status. Design: Seventeen stable patients without diabetes who were receiving hemodialysis were studied. In the first phase, AA losses were evaluated over 2 wk in 10 patients randomly assigned to receive AA supplementation. AA losses were analyzed during the first week without supplementation and during the second week with AA administration. In the second phase, the patients' nutritional status was investigated after 3 mo of AA supplementation and was compared with those in 7 patients not receiving AAs. Results: Mean ((x) over bar +/- SD) AA losses during a 4-h dialysis session were 12 +/- 2 g; there was a significant decrease in plasma AA concentrations (386 +/- 298 mu mol/L for essential and 902 +/- 735 mu mol/L for nonessential AAs). After administration of AAs, the losses increased to 28 +/- 4g. However, this procedure produced a positive net balance of AAs (10.6 +/- 5.6 g for total AAs), preventing a reduction in plasma concentrations. After 3 mo of AA administration, there was a significant increase in protein catabolic rate and serum albumin and transferrin. This improvement occurredwithout any change in the dialysis dose, ruling out the possibility that an increase in dialysis efficiency played a role. Conclusions: Intradialysis adequately provides AA supplements. prevents reductions in plasma AA concentrations, and favorably affects the nutritionalstatus of patients receiving hemodialysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:35:22