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Titolo:
Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease
Autore:
Engelen, MPKJ; Schols, AMWJ; Does, JD; Wouters, EFM;
Indirizzi:
Univ Hosp Mastricht, Dept Pulmonol, NL-6202 AZ Maastricht, Netherlands Univ Hosp Mastricht Maastricht Netherlands NL-6202 AZ richt, Netherlands Asthma Ctr Hornerheide, Horn, Netherlands Asthma Ctr Hornerheide Horn Netherlands Hornerheide, Horn, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 3, volume: 71, anno: 2000,
pagine: 733 - 738
SICI:
0002-9165(200003)71:3<733:SMWIAW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY ABSORPTIOMETRY; NUTRITIONAL DEPLETION; BODY-COMPOSITION; COPD; STRENGTH;
Keywords:
skeletal muscle weakness; extremity fat-free mass; chronic bronchitis; emphysema; chronic obstructive pulmonary disease; COPD; dual-energy X-ray absorptiometry; humans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Engelen, MPKJ Univ Hosp Mastricht, Dept Pulmonol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Mastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
M.P.K.J. Engelen et al., "Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease", AM J CLIN N, 71(3), 2000, pp. 733-738

Abstract

Background: Skeletal muscle weakness is a prominent problem in many patients with chronic obstructive pulmonary disease (COPD). Objective: The aim of the study was to determine the relation between skeletal muscle function, body composition, and lung function in COPD (emphysema and chronic bronchitis) patients and healthy volunteers. Design: In 50 patients with chronic bronchitis, 49 patients with emphysema, and 28 healthy volunteers, skeletal muscle function was assessed by handgrip and linear isokinetic dynamometry. Whole-body and subregional fat-free mass (FFM) were assessed by dual-energy X-ray absorptiometry. Results: Whole-body and extremity FFM were significantly lower in patientswith emphysema (P < 0.001) and chronic bronchitis (P < 0.05) than in healthy volunteers, but trunk FFM was significantly lower only in patients with emphysema (P < 0.001). Extremity FFM was not significantly different between the COPD subtype groups, despite significantly lower values for whole-body and trunk FFM (P < 0.05) in patients with emphysema. Absolute skeletal muscle function (P < 0.001) and muscle function per kilogram of whole-body FFM were significantly lower in both COPD subtype groups than in healthy volunteers (P < 0.05), but no significant difference was found between patientswith chronic bronchitis and those with emphysema. Muscle function per kilogram of extremity FFM was not significantly different between the 3 groups and was not associated with forced expiratory volume in 1 s. Conclusion: Skeletal muscle weakness is associated with wasting of extremity FFM in COPD patients, independent of airflow obstruction and COPD subtype.

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Documento generato il 08/07/20 alle ore 08:09:27