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Titolo:
Inhibitory effect of melatonin on products of lipid peroxidation resultingfrom chronic ethanol administration
Autore:
El-Sokkary, GH; Reiter, RJ; Tan, DX; Kim, SJ; Cabrera, J;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 truct Biol, San Antonio, TX 78284 USA Assiut Univ, Fac Sci, Dept Zool, Assiut, Egypt Assiut Univ Assiut EgyptAssiut Univ, Fac Sci, Dept Zool, Assiut, Egypt
Titolo Testata:
ALCOHOL AND ALCOHOLISM
fascicolo: 6, volume: 34, anno: 1999,
pagine: 842 - 850
SICI:
0735-0414(199911/12)34:6<842:IEOMOP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED OXIDATIVE DAMAGE; CARCINOGEN SAFROLE; BRAIN-REGIONS; RAT-LIVER; IN-VITRO; ALCOHOL; ANTIOXIDANT; INJURY; GLUTATHIONE; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Reiter, RJ Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr,San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 8284 USA
Citazione:
G.H. El-Sokkary et al., "Inhibitory effect of melatonin on products of lipid peroxidation resultingfrom chronic ethanol administration", ALC ALCOHOL, 34(6), 1999, pp. 842-850

Abstract

Despite decades of research, the role of free radicals in alcohol-induced organ injury is still a matter of debate. The present work was designed to investigate the potential protective effect of melatonin, a reported radical scavenger and antioxidant, on free radical toxicity induced by chronic ethanol administration. The major end-point of oxidative damage measured in this report was lipid peroxidation. Four groups of male Sprague-Dawley rats were used. The first group served as untreated controls and received a daily injection of alcoholic (<1% ethanol) saline. The second group of rats received daily at 18:00 a single subcutaneous injection of melatonin (10 mg/kg). Group a rats received only ethanol (3 g/kg) for 30 consecutive days; theethanol was given at 18:30. The final group of rats was given both melatonin and ethanol with melatonin preceding ethanol by 30 min. Products of lipid peroxidation [malondialdehyde (MDA) and 4-hydroxyalkenals (4-HDA)] were measured in the brain, heart, liver lung and testes. At the conclusion of the study, MDA + 4-HDA levels were significantly increased in brains, hearts,lungs and testes, but not livers, of alcohol-treated compared with controlrats. The percentage increases in lipid peroxidation products were 21.8%, 28.8%, 35.9% and 45.3% for brain, heart, lung and testes. respectively. In animals given melatonin 30 min before ethanol, the increases in MDA + 4-HDAlevels were significantly reduced in all organs investigated, with levels not different from those in control mts. Based on these findings, it is speculated that melatonin's direct and indirect antioxidative actions inhibited alcohol-induced lipid peroxidation. These results suggest a new strategy for the treatment of alcohol-related diseases using melatonin as an antioxidant to reduce the damage inflicted by aggressive radical species.

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Documento generato il 26/09/20 alle ore 14:20:14