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Titolo:
Natural history of serum HIV-1 RNA levels in 330 patients with a known date of infection
Autore:
Hubert, JB; Burgard, M; Dussaix, E; Tamalet, C; Deveau, C; Le Chenadec, J; Chaix, ML; Marchadier, E; Vilde, JL; Delfraissy, JF; Meyer, L; Rouzioux, C;
Indirizzi:
Hop Bicetre, INSERM, U292, F-94276 Le Kremlin Bicetre, France Hop BicetreLe Kremlin Bicetre France F-94276 Le Kremlin Bicetre, France Hop Bicetre, Dept Epidemiol, Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France emiol, Le Kremlin Bicetre, France Hop Bicetre, Dept Med, INSERM, U292, Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France U292, Le Kremlin Bicetre, France CHU Necker, Dept Virol, Paris, France CHU Necker Paris FranceCHU Necker, Dept Virol, Paris, France Hop Paul Brousse, Dept Microbiol, Villejuif, France Hop Paul Brousse Villejuif France se, Dept Microbiol, Villejuif, France Hop Enfants La Timone, Dept Virol, Marseille, France Hop Enfants La Timone Marseille France e, Dept Virol, Marseille, France Hop Bichat, Dept Med, Paris, France Hop Bichat Paris FranceHop Bichat, Dept Med, Paris, France
Titolo Testata:
AIDS
fascicolo: 2, volume: 14, anno: 2000,
pagine: 123 - 131
SICI:
0269-9370(20000128)14:2<123:NHOSHR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-1 RNA; CD4+ LYMPHOCYTE COUNTS; DISEASE PROGRESSION; LONGITUDINAL ANALYSIS; CUBIC MILLIMETER; CONTROLLED TRIAL; HOMOSEXUAL MEN; CELL COUNTS; VIRAL LOAD; AIDS-FREE;
Keywords:
disease progression; HIV-1 infection; longitudinal HIV-1 RNA levels; natural history;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Hubert, JB Hop Bicetre, INSERM, U292, 82 Rue Gen Leclerc, F-94276 Le Kremlin Bicetre,France Hop Bicetre 82 Rue Gen Leclerc Le Kremlin Bicetre FranceF-94276
Citazione:
J.B. Hubert et al., "Natural history of serum HIV-1 RNA levels in 330 patients with a known date of infection", AIDS, 14(2), 2000, pp. 123-131

Abstract

Objective: To describe the spontaneous course, before the introduction of highly active antiretroviral therapy (HAART), of HIV-1 RNA during the AIDS-free period of the disease. To assess the predictive value of changes in HIV-1 RNA levels. Design: A total of 330 patients with a known date of infection followed inthe SEROCO cohort. Methods: HIV-1 RNA levels (threshold, 200 copies/ml) were evaluated from 2243 frozen sera obtained from enrolment until the onset of AIDS or until February 1996. Lowess curves were used to describe the variations of viraemiaduring follow-up. A Cox regression model was used to assess the predictivevalue of early and updated CD4 cell count and viral load. Results: In addition to a lower early viral load, patients who remained AIDS-free had, on average, a longer period of viral load decrease after infection (36 versus 18 months), followed by a slower viral load increase compared with those who progressed to AIDS. A true plateau-phase after the seroconversion period, lasting approximately 4 years, was identified only in patients who remained AIDS-free for at least 90 months. In multivariate analysis, both early viral load and later changes were significant predictors of progression to AIDS. A decrease in the CD4 cell count to less than 200 cells/mu l and the onset of a group B condition remained significant predictors of progression. Conclusion: Our study extends to the early post-seroconversion phase the prognostic value of extracellular HIV-1 RNA levels. Moreover, our data suggest that, in most HIV-infected individuals, a progressive loss of control ofviral replication arises during the early years of HIV-1 infection. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:44:14