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Titolo:
A placebo-controlled comparison of zotepine versus chlorpromazine in patients with acute exacerbation of schizophrenia
Autore:
Cooper, SJ; Tweed, J; Raniwalla, J; Butler, A; Welch, C;
Indirizzi:
Queens Univ Belfast, Dept Mental Hlth, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland Knoll Pharmaceut, Nottingham, England Knoll Pharmaceut Nottingham England oll Pharmaceut, Nottingham, England
Titolo Testata:
ACTA PSYCHIATRICA SCANDINAVICA
fascicolo: 3, volume: 101, anno: 2000,
pagine: 218 - 225
SICI:
0001-690X(200003)101:3<218:APCOZV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; HALOPERIDOL;
Keywords:
chlorpromazine; negative symptoms; positive symptoms; schizophrenia; zotepine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, SJ Queens Univ Belfast, Dept Mental Hlth, Whitla Med Bldg,97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Whitla Med Bldg,97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
S.J. Cooper et al., "A placebo-controlled comparison of zotepine versus chlorpromazine in patients with acute exacerbation of schizophrenia", ACT PSYC SC, 101(3), 2000, pp. 218-225

Abstract

Objective: The aim of this study was to evaluate the efficacy of zotepine in the treatment of acute episodes of schizophrenia. Method: Patients with acute exacerbation of schizophrenia (DSM-III-R criteria; n = 158) were allocated on a random, double-blind basis to receive zotepine (150 or 300 mg/day), chlorpromazine (300 or 600 mg/ day) or placebo for 8 weeks. Symptoms were assessed on the BPRS, SANS and CCI scales at baseline and weeks 1, 2, 4, 6 and 8 and patients were assessed at these times for adverse effects. Analysis was by analysis of variance on the intent-to-treat population, with last observation carried forward. Results: Mean BPRS scores improved statistically significantly more with zotepine than chlorpromazine (point estimate of difference - 12.4, 95% CT - 18.3 to - 6.5) or placebo (point estimate of difference - 12.7, 95% CT -18.6 to -6.8). Zotepine produced significantly fewer extrapyramidal symptoms (EPS) than chlorpromazine. Conclusion: Zotepine is an effective antipsychotic with low propensity for EPS.

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Documento generato il 25/01/20 alle ore 19:18:54