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Titolo:
Contribution to the kinetics and amplitude of the electroretinogram b-waveby third-order retinal neurons in the rabbit retina
Autore:
Dong, CJ; Hare, WA;
Indirizzi:
RD 2C Allergan Inc, Dept Biol Sci, Irvine, CA 92612 USA RD 2C Allergan Inc Irvine CA USA 92612 ept Biol Sci, Irvine, CA 92612 USA
Titolo Testata:
VISION RESEARCH
fascicolo: 6, volume: 40, anno: 2000,
pagine: 579 - 589
SICI:
0042-6989(2000)40:6<579:CTTKAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIGER SALAMANDER RETINA; SOURCE-DENSITY ANALYSIS; AMINO-ACID SIGNATURES; HORIZONTAL CELLS; BIPOLAR CELLS; MUDPUPPY RETINA; EXTRACELLULAR-K+; GANGLION-CELLS; GATED CURRENTS; GABA RECEPTOR;
Keywords:
ERG; a-wave; b-wave; inner retina; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Dong, CJ RD 2C Allergan Inc, Dept Biol Sci, 2525 Dupont Dr, Irvine, CA 92612 USA RD 2C Allergan Inc 2525 Dupont Dr Irvine CA USA 92612 A 92612 USA
Citazione:
C.J. Dong e W.A. Hare, "Contribution to the kinetics and amplitude of the electroretinogram b-waveby third-order retinal neurons in the rabbit retina", VISION RES, 40(6), 2000, pp. 579-589

Abstract

The ERG b-wave is widely believed to reflect mainly light-induced activityof on-center bipolar cells and Muller cells. Third-order retinal neurons are thought to contribute negligibly to generation of the b-wave. Here we show that pharmacological agents which affect predominantly third-order neurons alter significantly both the kinetics and amplitude of the b-wave. Our results support the notion that changes in the amplitude and kinetics of right-induced membrane depolarization in third-order neurons produce similar changes in the amplitude and kinetics of the b-wave. We conclude that activity in third-order neurons makes a significant contribution to b-wave generation. Our results also provide evidence that spiking activity of third-order neurons truncates the a-wave by accelerating the onset of the b-wave. (C)2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:35:04