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Titolo:
Dose-dependent suppression by ethanol of transient auditory 40-Hz response
Autore:
Jaaskalainen, IP; Hirvonen, J; Saher, M; Pekkonen, E; Sillanaukee, P; Naatanen, R; Tiitinen, H;
Indirizzi:
Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 it, FIN-00014 Helsinki, Finland Univ Helsinki, Cent Hosp, Med Engn Ctr, BioMag Lab, Helsinki, Finland UnivHelsinki Helsinki Finland Engn Ctr, BioMag Lab, Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland Univ Helsinki Helsinki Finland ent Hosp, Dept Neurol, Helsinki, Finland Tampere Univ, Sch Med, FIN-33101 Tampere, Finland Tampere Univ Tampere Finland FIN-33101 h Med, FIN-33101 Tampere, Finland Pharmacia & Upjohn Diagnost R&D, Uppsala, Sweden Pharmacia & Upjohn Diagnost R&D Uppsala Sweden ost R&D, Uppsala, Sweden Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Dept Clin Neurosci, Stockholm, Sweden
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 148, anno: 2000,
pagine: 132 - 135
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL-CORTEX; OSCILLATIONS; ALCOHOL; HUMANS; PERFORMANCE; MECHANISM; CAT;
Keywords:
transient evoked 40-Hz response; gamma-band response; ERPs; alcohol; ethanol; selective attention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Jaaskalainen, IP Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, POB 13,Meritullinkatu 1, FIN-00014 Helsinki, Finland Univ Helsinki POB 13,Meritullinkatu 1 Helsinki Finland FIN-00014
Citazione:
I.P. Jaaskalainen et al., "Dose-dependent suppression by ethanol of transient auditory 40-Hz response", PSYCHOPHAR, 148(2), 2000, pp. 132-135

Abstract

Rationale: Acute alcohol (ethanol) challenge is known to induce various cognitive disturbances, yet the neural basis of the effect is poorly known. The auditory transient evoked gamma-band (40-Hz) oscillatory responses have been suggested to be associated with various perceptual and cognitive functions in humans; however, alcohol effects on auditory 40-Hz responses have not been investigated to date. Objectives: The objective of the study was totest the dose-related impact of alcohol on auditory transient evoked 40-Hzresponses during a selective-attention task. Methods: Ten healthy social drinkers ingested, in four separate sessions, 0.00, 0.25, 0.50, or 0.75 g/kgof 10% (v/v) alcohol solution. The order of the sessions was randomized and a double-blind procedure was employed. During a selective attention task,300-Hz standard and 330-Hz deviant tones were presented to the left ear, and 1000-Hz standards and 1100-Hz deviants to the right ear of the subjects (P=0.425 for each standard, P=0.075 for each deviant). The subjects attended to a designated ear, and were to detect the deviants therein while ignoring tones to the other ear. Results: The auditory transient evoked 40-Hz responses elicited by both the attended and unattended standard tones were significantly suppressed by the 0.50 and 0.75 g/kg alcohol doses. Conclusions:Alcohol suppresses auditory transient evoked 40-Hz oscillations already with moderate blood alcohol concentrations. Given the putative role of gamma-band oscillations in cognition, this finding could be associated with certain alcohol-induced cognitive deficits.

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Documento generato il 21/09/20 alle ore 16:12:52