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Titolo:
The role of genetic and early environmental factors in determining apomorphine susceptibility
Autore:
Ellenbroek, BA; Sluyter, F; Cools, AR;
Indirizzi:
Univ Nijmegen, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, NetherlandsUniv Nijmegen Nijmegen Netherlands NL-6500 HB 0 HB Nijmegen, Netherlands
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 148, anno: 2000,
pagine: 124 - 131
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL ACTIVITY; MATERNAL SEPARATION; WISTAR RATS; ADULT-RATS; AMPHETAMINE; STRESS; SCHIZOPHRENIA; PLASTICITY;
Keywords:
apormorphine; genetic factor; environmental factor; susceptibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ellenbroek, BA Univ Nijmegen, Dept Psychoneuropharmacol, POB 9101, NL-6500HB Nijmegen, Netherlands Univ Nijmegen POB 9101 Nijmegen Netherlands NL-6500 HB nds
Citazione:
B.A. Ellenbroek et al., "The role of genetic and early environmental factors in determining apomorphine susceptibility", PSYCHOPHAR, 148(2), 2000, pp. 124-131

Abstract

Rationale: There is ample evidence that rats show large individual differences in their response to dopaminergic drugs, such as apomorphine. Objective: The aim of the present study was to investigate the role of genetic and (early) environmental factors in determining the adult susceptibility to apomorphine. Four experiments were performed: In experiment 1, the original selective breeding of rats for apomorphine susceptibility (leading to APO-SUS and APO-UNSUS rats) was extended and replicated in an independent group of Wistar rats. In experiment 2, APO-SUS males were cross-bred with APO-UNSUS females and vice versa. In experiment 3 APO-SUS litters were cross-fostered to APO-UNSUS mothers or infostered to unknown APO-SUS mothers and vice versa. In experiment 4 APO-SUS and APO-UNSUS rats were maternally deprived on postnatal day 9, for a single 24-h period. Methods: Adult rats were subcutaneously injected with 1.5 mg/kg apomorphine and their gnawing response was automatically recorded in a gnawing box for 45 min. Results: In experiment I, the original breeding was extended up to generation 24, leading to a strong and consistent difference in gnawing scores. The replication experiment also succeeded in differentiating APO-SUS and APO-UNSUS. The cross breeding experiments showed that the APO-SUS/UNSUS offspring showed gnawing scores in between the original selection lines. Cross-fostering APO-SUS with APO-UNSUS significantly reduced the gnawing response in the offspring, whereas it did not affect the gnawing score in the APO-UNSUS animals. Maternal deprivation had the opposite effect: increase in gnawing response in APO-UNSUS, with no effect in APO-SUS. Conclusion: The results show a clear-cut contribution of both genetic and early environmental factors to the susceptibility of apomorphine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:45:57