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Titolo:
Distribution of amyloid beta protein precursor in the Alzheimer's disease brain
Autore:
Shoji, M; Kawarabayashi, T; Matsubara, E; Ikeda, M; Ishiguro, K; Harigaya, Y; Okamoto, K;
Indirizzi:
Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 1, volume: 54, anno: 2000,
pagine: 45 - 54
SICI:
1323-1316(200002)54:1<45:DOABPP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENILE PLAQUES; MESSENGER-RNA; DEMENTIA; LOCALIZATION; EXPRESSION; DIAGNOSIS; NEURITES; GENE;
Keywords:
Alzheimer's disease; amyloid beta protein precursor; immunocytochemistry; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Shoji, M Gunma Univ, Sch Med, Dept Neurol, 3-39-15 Showa Machi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-15 Showa Machi Maebashi Gumma Japan 3718511 Japan
Citazione:
M. Shoji et al., "Distribution of amyloid beta protein precursor in the Alzheimer's disease brain", PSY CLIN N, 54(1), 2000, pp. 45-54

Abstract

In order to clarify the distribution and pathological changes of the amyloid beta protein precursor (beta APP), 10 Alzheimer's disease (AD) brains and seven normal control brains were examined by immunocytochemistry and in situ hybridization histochemistry. All beta APP isoforms were distributed evenly in neuronal cell bodies and their axone and dendrites. The beta APP-positive neuronal processes showed mesh-like networks. In AD brains, beta APP-positive neurons and mesh-like net works were generally decreased in spiteof some intensely labeled neurons. All beta APP isoforms accumulated in neuronal processes, dystrophic neurites and senile plaques. In situ hybridization histochemistry confirmed that all isoforms of beta APP were expressed in neurons in control brains. In AD brains, the beta APP mRNA signal was generally decreased besides some intense signal neurons corresponding to immunostaining findings. Few astrocytes expressed beta APP. Thus, uniform expression and distribution of beta APP were disturbed in AD brains showing uneven decreases or increases of neuronal beta APP expression in individual neurons and beta APP accumulation in neurons, neuronal processes and abnormal structures including dystrophic neurites, senile plaques and neurofibrillary tangles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:33:22