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Titolo:
Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews
Autore:
Van Kampen, M; Schmitt, U; Hiemke, C; Fuchs, E;
Indirizzi:
German Primate Ctr, Div Neurobiol, D-37077 Gottingen, Germany German Primate Ctr Gottingen Germany D-37077 D-37077 Gottingen, Germany Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 65, anno: 2000,
pagine: 539 - 546
SICI:
0091-3057(200003)65:3<539:DHNBEO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR-BINDING; RAT CORTICOSTERONE RESPONSE; ELEVATED PLUS-MAZE; PLASMA CORTICOSTEROIDS; PSYCHOSOCIAL STRESS; TUPAIA-BELANGERI; BRAIN CATECHOLAMINES; MINOR TRANQUILIZERS; CHLORDIAZEPOXIDE; ANXIETY;
Keywords:
anxiety; depression; cortisol; noradrenaline; avoidance behavior; marking behavior; locomotor activity; animal models; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, E German Primate Ctr, Div Neurobiol, Kellnerweg 4, D-37077 Gottingen, Germany German Primate Ctr Kellnerweg 4 Gottingen Germany D-37077 ermany
Citazione:
M. Van Kampen et al., "Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews", PHARM BIO B, 65(3), 2000, pp. 539-546

Abstract

The present study evaluated the effect of subchronic oral treatment of psychosocially stressed male tree shrews with diazepam on locomotor activity, marking behavior, avoidance behavior, and urinary cortisol and noradrenaline. To mimic a realistic situation of anxiolytic intervention, the treatmentstarted 14 days after the beginning of psychosocial stress; at that time, the stress-induced behavioral and endocrine alterations had been established. The drug (5 mg/kg/day) was administered orally in the morning, while thepsychosocial stress continued during the whole treatment period; the therapeutic action of diazepam treatment was followed across 7 days. Twenty-fourhours after the last application serum concentrations of diazepam and its major metabolites were determined via HPLC. The results revealed concentrations of 7 ng/ml for diazepam, 106 ng/ml for nordiazepam, 22 ng/ml for temazepam, and 30 ng/ml for oxazepam. Treatment of subordinate animals with diazepam did not reveal a beneficial effect to any of the parameters studied. This contrasts to earlier findings showing that the behavioral and neuroendocrine alterations produced by this stress paradigm are sensitive to chronictreatment with the tricyclic antidepressant clomipramine. The present results support the view that in male tree shrews the state induced by psychosocial stress might be more depression related than anxiety related. (C) 2000Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:39:37