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Titolo:
PD-135,158, a cholecystokinin(B) antagonist, enhances latent inhibition inthe rat
Autore:
Gracey, DJ; Bell, R; King, DJ;
Indirizzi:
Queens Univ Belfast, Sch Psychol, Belfast BT7 1NN, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT7 1NN m, North Ireland Queens Univ Belfast, Dept Therapeut & Pharmacol, Belfast BT7 1NN, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT7 1NN m, North Ireland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 65, anno: 2000,
pagine: 459 - 463
SICI:
0091-3057(200003)65:3<459:PACAEL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDBRAIN DOPAMINE NEURONS; ANTIPSYCHOTIC-DRUGS; HEALTHY PEOPLE; D-AMPHETAMINE; UNIT-ACTIVITY; HALOPERIDOL; SCHIZOPHRENIA; MODEL; CCK; RECEPTOR;
Keywords:
PD-135,158; CCK; latent inhibition; rat model of psychosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Bell, R Queens Univ Belfast, Sch Psychol, David Keir Bldg, Belfast BT7 1NN, Antrim, North Ireland Queens Univ Belfast David Keir Bldg Belfast Antrim North Ireland BT7 1NN
Citazione:
D.J. Gracey et al., "PD-135,158, a cholecystokinin(B) antagonist, enhances latent inhibition inthe rat", PHARM BIO B, 65(3), 2000, pp. 459-463

Abstract

The antipsychotic potential of cholecystokinin (CCK)-related compounds stems from CCK's colocalization with dopamine (DA). CCK demonstrates excitatory and inhibitory effects on DA in the mesolimbic pathway. Such diverse actions might be mediated by different receptor subtypes (CCKA or CCKB). Multiple hypotheses have emerged regarding the clinical application of CCK-based drugs. Administering selective nonpeptide antagonists within animal models relevant to schizophrenia would help delineate CCK receptor involvement. One animal model simulating a cognitive dysfunction of schizophrenia is latent inhibition (LI). An animal repeatedly exposed to a stimulus that is devoid of consequence is subsequently inhibited in making new associations with that stimulus. This reflects a process of learning to ignore irrelevant stimuli. The present study examined the effects of the selective CCKB antagonist PD-135,158 (0.001, 0.01, and 0.1 mg/kg) using a conditioned suppression of drinking procedure in rats. For purposes of comparison the effects of haloperidol (0.1 mg/kg) were also investigated. PD-135,158 (0.1 mg/kg), similar to haloperidol (0.1 mg/kg), elicited a clear LI effect under conditions that did not lead to LI in control rats (low number of preexposures). Thesefindings highlight the antipsychotic potential of CCKB antagonists, and further illustrate the LI paradigm's capacity to detect novel, antipsychotic-like, drug activity. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:48:16