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Titolo:
Differences between males and females in risk of NSAID-related severe gastrointestinal events
Autore:
Neutel, CI; Maxwell, CJ; Appel, WC;
Indirizzi:
Hlth Canada, Therapeut Prod Directorate, Ottawa, ON K1A 0L2, Canada Hlth Canada Ottawa ON Canada K1A 0L2 ectorate, Ottawa, ON K1A 0L2, Canada Univ Calgary, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 lgary, Calgary, AB T2N 4N1, Canada Kusuri Canada Corp, Stn T, Ottawa, ON K1G 3H7, Canada Kusuri Canada Corp Ottawa ON Canada K1G 3H7 T, Ottawa, ON K1G 3H7, Canada
Titolo Testata:
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
fascicolo: 7, volume: 8, anno: 1999,
pagine: 501 - 507
SICI:
1053-8569(199912)8:7<501:DBMAFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTI-INFLAMMATORY DRUGS; PEPTIC-ULCER DISEASE; ELDERLY PERSONS; HOSPITALIZATION; SASKATCHEWAN; PERFORATION; HEMORRHAGE;
Keywords:
NSAID; GI complications; adverse effects; male/female differences; effect modification; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Neutel, CI SCOHS, Dept Res, 43 Bruyere St, Ottawa, ON, Canada SCOHS 43 Bruyere St Ottawa ON Canada re St, Ottawa, ON, Canada
Citazione:
C.I. Neutel et al., "Differences between males and females in risk of NSAID-related severe gastrointestinal events", PHARMA D S, 8(7), 1999, pp. 501-507

Abstract

Purpose - NSAID use has long been established as a risk factor for severe gastrointestinal (GI) events. It is also known that age and gender affect the risk of such events independently of nonsteroidal antiinflammatory drug (NSAID) use. The objective of the present study is to distinguish between gender as an independent risk factor for severe GI events, and the differences between males and females in risk of NSAID-related severe GI events. Methods - The study design was a nested case-control study. During the study period, 1029 cases were hospitalized with GI bleeds and/or perforations and 14481 controls without such GI events were selected. Exposure consistedof the number of NSAID prescriptions dispensed by a pharmacy, prior to thedata of hospitalization for cases and a corresponding date for controls. Results - Males have a risk of serious GI events 1.4 times greater than females, independent of NSAID use. However, females have the greater increasein risk of NSAID-related GI events, e.g.. at four prescriptions women havean odds ratio (OR) of 7.4 (p < 0.05), while men have a corresponding OR of3.2 (p < 0.05). The increasing risk of severe GI events with number of NSAID prescriptions was considerably greater for females than for males, indicating effect-modification. In a stratified analysis by age and gender, it was clear that gender was the greater influence, Various metabolic and epidemiological potential explanations are discussed. Conclusions - Age and gender are separate risk factors for GI complications as related to NSAID use. Although implied in other studies, the effect ofgender on the risk of NSAID-related GI events is dearly stated in this study. Copyright (C) 1999 John Wiley & Sons, Ltd.

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Documento generato il 18/02/20 alle ore 05:33:54