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Titolo:
Association of concentration of asbestos and asbestos-like fibers with thepatient's survival and the binding capacity of lung parenchyma to galectin-1 and natural alpha-galactoside- and alpha-mannoside-binding immunoglobulin G subfractions from human serum
Autore:
Kayser, K; Seemann, C; Andre, S; Kugler, C; Becker, C; Dong, X; Kaltner, H; Gabius, HJ;
Indirizzi:
Thoraxklin, Dept Pathol, Heidelberg, Germany Thoraxklin Heidelberg Germany raxklin, Dept Pathol, Heidelberg, Germany Univ Munich, Inst Physiol Chem, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 t Physiol Chem, D-8000 Munich, Germany Thoraxklin, Dept Thorac Surg, Heidelberg, Germany Thoraxklin Heidelberg Germany in, Dept Thorac Surg, Heidelberg, Germany
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 2, volume: 196, anno: 2000,
pagine: 81 - 87
SICI:
0344-0338(2000)196:2<81:AOCOAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRYSOTILE ASBESTOS; EXPRESSION; CELL; DEPOSITION; CLEARANCE; RESPONSES; EXPOSURE; RECEPTOR; DISEASE; PRODUCT;
Keywords:
asbestos; autoantibody; calcyclin; galectin; lung cancer; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kayser, K Thoraxklin, Dept Pathol, Heidelberg, Germany Thoraxklin Heidelberg Germany ept Pathol, Heidelberg, Germany
Citazione:
K. Kayser et al., "Association of concentration of asbestos and asbestos-like fibers with thepatient's survival and the binding capacity of lung parenchyma to galectin-1 and natural alpha-galactoside- and alpha-mannoside-binding immunoglobulin G subfractions from human serum", PATH RES PR, 196(2), 2000, pp. 81-87

Abstract

Our aim in this study was to search for lung parenchyma alterations associated with asbestos and/or asbestos-like fiber concentration. This was done by means of immuno- or glycohistochemistry. The hot-ashing technique determined the asbestos and asbestos-like fiber concentrations in the lung tissues of 100 patients of whom 52 were treated for primary lung and 25 for secondary lung tumors; fiber concentration was also measured for 23 patients whose disease was benign. The results were correlated to smoking habits, survival of the patients, and expression of binding capacities for endogenous lectins, natural carbohydrate-binding and lectin-specific antibodies. The cohort with proven asbestos exposure revealed a mean fiber concentration 114 f/g compared to 95 f/g in the non-exposed group. An increased asbestos fiber concentration was correlated to galectin-1-binding and the presence of epitopes for natural immunoglobulin G subfractions with selectivity toalpha-galactosides and alpha-mannosides. The survival of patients with primary and secondary lung tumors was negatively associated with the fiber concentration. The data indicate that increased presence of asbestos is correlated with an alteration of defined glycohistochemical features of alveolar lining cells.

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Documento generato il 28/11/20 alle ore 12:46:42