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Titolo:
Expression of scavenger receptor class A and CD14 in lipopolysaccharide-induced lung injury
Autore:
Yamamoto, T; Ebe, Y; Hasegawa, G; Kataoka, M; Yamamoto, S; Naito, M;
Indirizzi:
Niigata Univ, Sch Med, Dept Pathol 2, Niigata 9518510, Japan Niigata UnivNiigata Japan 9518510 Dept Pathol 2, Niigata 9518510, Japan Oita Med Univ, Dept Pathol, Oita, Japan Oita Med Univ Oita JapanOita Med Univ, Dept Pathol, Oita, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 11, volume: 49, anno: 1999,
pagine: 983 - 992
SICI:
1320-5463(199911)49:11<983:EOSRCA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; LPS-BINDING-PROTEIN; IN-VIVO; APOPTOTIC THYMOCYTES; EPITHELIAL-CELLS; LIGAND-BINDING; SOLUBLE CD14; MACROPHAGE; MOUSE; ENDOTOXIN;
Keywords:
CD14; lipopolysaccharide; lung; macrophage colony stimulating factor; macrophages; scavenger receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Naito, M Niigata Univ, Sch Med, Dept Pathol 2, Asahimachi Dori 1, Niigata 9518510, Japan Niigata Univ Asahimachi Dori 1 Niigata Japan 9518510 8510, Japan
Citazione:
T. Yamamoto et al., "Expression of scavenger receptor class A and CD14 in lipopolysaccharide-induced lung injury", PATHOL INT, 49(11), 1999, pp. 983-992

Abstract

CD14 and macrophage scavenger receptor class A type I and II (MSR-A) are receptors for lipopolysaccharide (LPS), In this study, the expressions of both receptors in the lung after administration of LPS in aerosol to mice with a nebulizer were observed. Bronchiolar epithelial cells and alveolar macrophages immediately incorporated LPS and expressed CD14, CD14-positive neutrophils then appeared in the alveolar-space followed by the appearance of MSR-A-expressing cells in the-vascular lumen, pulmonary interstitium, and alveolar Space. Numbers of apoptotic cells increased after 1 day, and MSR-A-expressing macrophages actively incorporated apoptotic bodies. Daily administration of macrophage colony stimulating factor (M-CSF) to the mice resulted in increased levels of MSR-A expression and reduced levels of CD14 as well as several cytokine expressions, leading to shortening of the inflammatory process. The numbers of apoptotic cells were reduced in M-CSF injected mice. These findings imply that CD14 acts as an immediate expressing receptorfor LPS and MSR-A exerts a protective function by scavenging LPS and apoptotic cells in LPS-induced lung injury.

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Documento generato il 04/06/20 alle ore 11:27:22