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Titolo:
Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography
Autore:
Herrmann, M; Jost, S; Kutz, S; Ebert, AD; Kratz, T; Wunderlich, MT; Synowitz, H;
Indirizzi:
Otto Von Guericke Univ, Fac Med, Div Neuropsychol & Behav Neurol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Otto Von Guericke Univ, Dept Neurol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Otto Von Guericke Univ, Dept Neurosurg, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 2, volume: 17, anno: 2000,
pagine: 113 - 122
SICI:
0897-7151(200002)17:2<113:TPORON>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; MINOR HEAD-INJURY; CALCIUM-BINDING PROTEINS; DIFFUSE AXONAL INJURY; S-100 PROTEIN; CARDIOPULMONARY BYPASS; SERUM MARKER; CELL-DEATH; ASTROCYTES; S100-BETA;
Keywords:
CCT; NSE; protein S-100B; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Herrmann, M Otto Von Guericke Univ, Fac Med, Div Neuropsychol & Behav Neurol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
M. Herrmann et al., "Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography", J NEUROTRAU, 17(2), 2000, pp. 113-122

Abstract

This study aimed at the investigation of release patterns of neuron specific enolase (NSE) and protein S-100B after traumatic brain injury (TBI) and their association with intracranial pathologic changes as demonstrated in computerized tomography (CT). We analyzed NSE and S-100B concentrations in serial venous blood samples taken one to three days after TBI in 66 patientsby the use of immunoluminometric assays. These markers are considered to be specific neurobiochemical indicators of damage to glial (S-100B) or neuronal (NSE) brain tissue. Standardized neurological examination and plani- and volumetric evaluation of computerized tomography scans were performed in all patients. Patients with medium severe to severe TBI [Glasgow Coma Scale(GCS) score at the site of accident less than or equal to 12] exhibited significantly higher NSE and S-100B concentrations and a significantly longerrelease compared to patients with minor head injury (GCS: 13-15). Both, patients with and without visible intracerebral pathology in CT scans exhibited elevated concentrations of NSE and S-100B after TBI and a significant decrease in the follow-up blood samples. Release patterns of S-100B and NSE differed in patients with primary cortical contusions, diffuse axonal injury(DAI), and signs of cerebral edema (ICP) without focal mass lesions. All serum concentrations of NSE and S-100B were significantly correlated with the volume of contusions. The data of the present study indicate that the early release patterns of NSE and S-100 may mirror different pathophysiological consequences of traumatic brain injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:34:18