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Titolo:
Afferent regulation of inhibitory synaptic transmission in the developing auditory midbrain
Autore:
Vale, C; Sanes, DH;
Indirizzi:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Dept Biol, New York, NY 10003 USA NYU New York NY USA 10003NYU, Dept Biol, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 20, anno: 2000,
pagine: 1912 - 1921
SICI:
0270-6474(20000301)20:5<1912:AROIST>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY COMPLEX; RAT INFERIOR COLLICULUS; EAR OSSICLE REMOVAL; COCHLEAR NUCLEUS; LATERAL LEMNISCUS; GLYCINERGIC TRANSMISSION; POSTNATAL-DEVELOPMENT; RESPONSE PROPERTIES; DORSAL NUCLEUS; MOUSTACHE BAT;
Keywords:
GABA(A) receptor; glycine receptor; inferior colliculus; inhibitory; gerbil; deafness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Sanes, DH NYU, Ctr Neural Sci, 4 Washington Pl, New York, NY 10003 USA NYU4 Washington Pl New York NY USA 10003 New York, NY 10003 USA
Citazione:
C. Vale e D.H. Sanes, "Afferent regulation of inhibitory synaptic transmission in the developing auditory midbrain", J NEUROSC, 20(5), 2000, pp. 1912-1921

Abstract

To determine whether afferent innervation regulates the strength of inhibitory connections in the gerbil auditory midbrain, both cochleas were surgically removed in postnatal day 7 animals, before sound-driven activity is first observed. Inhibitory synaptic currents were measured in a brain slice preparation 1-7 d after the ablations. Whole-cell and gramicidin-perforated patch recordings were obtained from inferior colliculus neurons, and IPSCs were evoked by stimulation of the commissure of the inferior colliculus (CIC) or the ipsilateral lateral lemniscus (LL) in the presence of kynurenic acid. Deafferentation led to a 24 mV depolarizing shift in the IPSC equilibrium potential within 1 d of deafferentation. As a consequence, there was a large reduction of IPSC amplitude at a holding potential of -20 mV in neurons from bilaterally ablated animals. Furthermore, both afferent pathways displayed a 50% reduction of the inhibitory synaptic conductance after deafferentation, indicating that driving force was not solely responsible for thedecline in IPSC amplitude. When paired pulses were delivered to the LL or CIC pathway in control neurons, the evoked IPSCs exhibited facilitation. However, paired pulse facilitation was nearly eliminated after deafferentation. Thus, normal innervation affects inhibitory synaptic strength by regulating postsynaptic chloride homeostasis and presynaptic transmitter release properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:09:41