Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Brain-derived neurotrophic factor acutely inhibits AMPA-mediated currents in developing sensory relay neurons
Autore:
Balkowiec, A; Kunze, DL; Katz, DM;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 20, anno: 2000,
pagine: 1904 - 1911
SICI:
0270-6474(20000301)20:5<1904:BNFAIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; HIPPOCAMPAL SYNAPTIC TRANSMISSION; GLUTAMATE-INDUCED NEUROTOXICITY; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; FACTOR MESSENGER-RNA; NON-NMDA RECEPTORS; RAT VISUAL-CORTEX; TYROSINE PHOSPHORYLATION; ADULT HIPPOCAMPUS;
Keywords:
AMPA; BDNF; glutamate; nucleus tractus solitarius; sensory neurons; synaptic plasticity; synaptic transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, DM Case Western Reserve Univ, Sch Med, Dept Neurosci, 10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
A. Balkowiec et al., "Brain-derived neurotrophic factor acutely inhibits AMPA-mediated currents in developing sensory relay neurons", J NEUROSC, 20(5), 2000, pp. 1904-1911

Abstract

Brain-derived neurotrophic factor (BDNF) is expressed by many primary sensory neurons that no longer require neurotrophins for survival, indicating that BDNF may be used as a signaling molecule by the afferents themselves. Because many primary afferents also express glutamate, we investigated the possibility that BDNF modulates glutamatergic AMPA responses of newborn second-order sensory relay neurons. Perforated-patch, voltage-clamp recordings were made from dissociated neurons of the brainstem nucleus tractus solitarius (nTS), a region that receives massive primary afferent input from BDNF-containing neurons in the nodose and petrosal cranial sensory ganglia. Electrophysiological analysis was combined in some experiments with anterogradelabeling of primary afferent terminals to specifically analyze responses of identified second-order neurons. Our data demonstrate that BDNF strongly inhibits AMPA-mediated currents in a large subset of nTS cells. Specifically, AMPA responses were either completely abolished or markedly inhibited byBDNF in 73% of postnatal day (P0) cells and in 82% of identified P5 second-order sensory relay neurons. This effect of BDNF is mimicked by NT-4, but not NGF, and blocked by the Trk tyrosine kinase inhibitor K252a, consistentwith a requirement for TrkB receptor activation. Moreover, analysis of TrkB expression in culture revealed a close correlation between the percentageof nTS neurons in which BDNF inhibits AMPA currents and the percentage of neurons that exhibit TrkB immunoreactivity. These data document a previously undefined mechanism of acute modulation of AMPA responses by BDNF and indicate that BDNF may regulate glutamatergic transmission at primary afferentsynapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:01:29