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Titolo:
Characteristics of plateau activity during the latent period prior to epileptiform discharges in slices from rat piriform cortex
Autore:
Demir, R; Haberly, LB; Jackson, MB;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Physiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Physiol, Madison, WI 53706 USA Univ Wisconsin, Sch Med, Dept Anat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Med, Dept Anat, Madison, WI 53706 USA Univ Wisconsin, Sch Med, Ctr Neurosci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Ctr Neurosci, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 2, volume: 83, anno: 2000,
pagine: 1088 - 1098
SICI:
0022-3077(200002)83:2<1088:COPADT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEEP PREPIRIFORM CORTEX; VOLTAGE-SENSITIVE DYE; ENDOPIRIFORM NUCLEUS; POTENTIALS; ANTAGONISTS; GENERATION; SEIZURES; EPSPS; CELLS; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, MB Univ Wisconsin, Sch Med, Dept Physiol, SMI 127,1300 Univ Ave, Madison, WI 53706 USA Univ Wisconsin SMI 127,1300 Univ Ave Madison WI USA 53706 USA
Citazione:
R. Demir et al., "Characteristics of plateau activity during the latent period prior to epileptiform discharges in slices from rat piriform cortex", J NEUROPHYS, 83(2), 2000, pp. 1088-1098

Abstract

Characteristics of plateau activity during the latent period prior to epileptiform discharges in slices from rat piriform cortex. J. Neurophysiol. 83: 1088-1098, 2000. The deep piriform region has an unusually high seizure susceptibility. Voltage imaging previously located the sites of epileptiformdischarge onset in slices of rat piriform cortex and revealed the spatiotemporal pattern of development of two types of electrical activity during the latent period prior to discharge onset. A ramplike depolarization (onset activity) appears at the site of discharge onset. Onset activity is preceded by a sustained low-amplitude depolarization (plateau activity) at anothersite, which shows little if any overlap with the site of onset. Because synaptic blockade at either of these two sites blocks discharges, it was proposed that both forms of latent period activity are necessary for the generation of epileptiform discharges and that the onset and plateau sites work together in the amplification of electrical activity. The capacity for amplification was examined here by studying subthreshold responses in slices of piriform cortex using two different in vitro models of epilepsy. Under someconditions electrically evoked responses showed a nonlinear dependence on stimulus current, suggesting amplification by strong polysynaptic excitatory responses. The sites of plateau and onset activity were mapped for different in vitro models of epilepsy and different sites of stimulation. These experiments showed that the site of plateau activity expanded into deep layers of neighboring neocortex in parallel with expansions of the onset site into neocortex. These results provide further evidence that interactions between the sites of onset and plateau activity play an important role in the initiation of epileptiform discharges. The site of plateau activity showed little variation with different stimulation sires in the piriform cortex, but when stimulation was applied in the endopiriform nucleus (in the sites of onset of plateau activity), plateau activity had a lower amplitude and became distributed over a much wider area. These results indicate that in theinitiation of epileptiform discharges, the location of the circuit that generates plateau activity is not rigidly defined but can exhibit flexibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:28:26