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Titolo:
Detection of minimal levels of serum anti-Mullerian hormone during follow-up of patients with ovarian granulosa cell tumor by means of a highly sensitive enzyme-linked immunosorbent assay
Autore:
Long, WQ; Ranchin, V; Pautier, P; Belville, C; Denizot, P; Cailla, H; Lhomme, C; Picard, JY; Bidart, JM; Rey, R;
Indirizzi:
Ecole Normale Super, Dept Biol, INSERM, Unite Rech Endocrinol Dev, F-92120Montrouge, France Ecole Normale Super Montrouge France F-92120 v, F-92120Montrouge, France Inst Gustave Roussy, Dept Biol Clin, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Gynecol Serv, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Immunotech SA, Dept Immunoanalyse, F-13276 Marseille, France Immunotech SA Marseille France F-13276 nalyse, F-13276 Marseille, France
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 85, anno: 2000,
pagine: 540 - 544
SICI:
0021-972X(200002)85:2<540:DOMLOS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITING SUBSTANCE; STROMAL TUMORS; MARKER; ACTIVIN; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rey, R Hosp Ninos Dr Ricardo Gutierrez, Ctr Invest Endocrinol, Gallo 1330,RA-1425 Buenos Aires, DF, Argentina Hosp Ninos Dr Ricardo Gutierrez Gallo 1330 Buenos Aires DF Argentina RA-1425
Citazione:
W.Q. Long et al., "Detection of minimal levels of serum anti-Mullerian hormone during follow-up of patients with ovarian granulosa cell tumor by means of a highly sensitive enzyme-linked immunosorbent assay", J CLIN END, 85(2), 2000, pp. 540-544

Abstract

Granulosa cell tumors (GCT) are ovarian neoplasms that tend to recur and spread in the pelvis and the abdomen several years after the initial treatment. Anti-Mullerian hormone (AMH) is a reliable serum marker of these tumors. To enhance the availability and the sensitivity of serum AMH determination, Re developed an ultrasensitive enzyme-linked immunosorbent assay. In this work we compare the results of serum AMH levels, obtained using the ultrasensitive and the traditional assays, in 31 patients with ovarian GCT followed up for up to 7 yr. The ultrasensitive enzyme-linked immunosorbent assay has a significantly higher sensitivity than the traditional one. This resulted in the detection of low serum AMH levels, which were undetectable with the traditional assay, in several cases including one patient in whom a recurrence of a GCT had developed and two patients in whom the treatment had not been completely successful. These cases highlight the importance of the availability of a highly sensitive assay allowing evaluation with high precision of the results of treatment and to detect the recurrences of GCT at an early, preclinical stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:05:28