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Titolo:
Measurement of striatal and extrastriatal dopamine D-1 receptor binding potential with [C-11]NNC 112 in humans: Validation and reproducibility
Autore:
Abi-Dargham, A; Martinez, D; Mawlawi, O; Simpson, N; Hwang, DR; Slifstein, M; Anjilvel, S; Pidcock, J; Guo, NN; Lombardo, I; Mann, JJ; Van Heertum, R; Foged, C; Halldin, C; Laruelle, M;
Indirizzi:
New York State Psychiat Inst, Dept Neurosci, Div Brain Imaging, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Karolinska Inst, Stockholm, Sweden Karolinska Inst Stockholm SwedenKarolinska Inst, Stockholm, Sweden Novo Nordisk AS, Malov, Denmark Novo Nordisk AS Malov DenmarkNovo Nordisk AS, Malov, Denmark
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 2, volume: 20, anno: 2000,
pagine: 225 - 243
SICI:
0271-678X(200002)20:2<225:MOSAED>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; HUMAN-BRAIN; D1 RECEPTORS; BENZODIAZEPINE RECEPTORS; AUTOMATED ALGORITHM; GRAPHICAL ANALYSIS; PREFRONTAL CORTEX; SPECT MEASUREMENT; 5-HT2A RECEPTORS; PET EXAMINATION;
Keywords:
positron emission tomography; dopamine; D-1 receptors; [C-11]NNC 112;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Abi-Dargham, A New York State Psychiat Inst, Dept Neurosci, Div Brain Imaging, 1051 Riverside Dr,Unit 42, New York, NY 10032 USA New York State Psychiat Inst 1051 Riverside Dr,Unit 42 New York NY USA 10032
Citazione:
A. Abi-Dargham et al., "Measurement of striatal and extrastriatal dopamine D-1 receptor binding potential with [C-11]NNC 112 in humans: Validation and reproducibility", J CEREBR B, 20(2), 2000, pp. 225-243

Abstract

To evaluate the postulated role of extrastriatal D-1 receptors in human cognition and psychopathology requires an accurate and reliable method for quantification of these receptors in the living human brain. [C-11]NNC 112 isa promising novel radiotracer for positron emission tomography imaging of the D-1 receptor. The goal of this study was to develop and evaluate methods to derive D-1 receptor parameters in striatal and extrastriatal regions of the human brain with [C-11]NNC 112. Six healthy volunteers were studied twice. Two methods of analysis (kinetic and graphical) were applied to 12 regions (neocortical, limbic, and subcortical regions) to derive four outcomemeasures: total distribution volume, distribution volume ratio, binding potential (BP), and specific-to-nonspecific equilibrium partition coefficient(k(3)/k(4)). Both kinetic and graphic analyses provided BP and k(3)/k(4) values in good agreement with the known distribution of D-1 receptors (striatum > limbic regions = neocortical regions > thalamus). The identifiabilityof outcome measures derived by kinetic analysis was excellent. Time-stability analysis indicated that 90 minutes of data collection generated stable outcome measures. Derivation of BP and k(3)/k(4) by kinetic analysis was highly reliable, with intraclass correlation coefficients (ICCs) of 0.90 +/- 0.06 (mean +/- SD of 12 regions) and 0.84 +/- 0.11, respectively. The reliability of these parameters derived by graphical analysis was lower, with ICCs of 0.72 +/- 0.17 and 0.58 +/- 0.21, respectively. Noise analysis revealed a noise-dependent bias in the graphical but not the kinetic analysis. In conclusion, kinetic analysis of [C-11]NNC 112 uptake provides an appropriate method with which to derive D-1 receptor parameters in regions with both high (striatal) and low (extrastriatal) D-1 receptor density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:10:50