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Titolo:
Mapping the visual recognition memory network with PET in the behaving baboon
Autore:
Blaizot, X; Landeau, B; Baron, JC; Chavoix, C;
Indirizzi:
INSERM, U320, Ctr Cyceron, F-14074 Caen, France INSERM Caen France F-14074 SERM, U320, Ctr Cyceron, F-14074 Caen, France CEA, DSV, DRM, F-14074 Caen, France CEA Caen France F-14074CEA, DSV, DRM, F-14074 Caen, France
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 2, volume: 20, anno: 2000,
pagine: 213 - 219
SICI:
0271-678X(200002)20:2<213:MTVRMN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ENTORHINAL CORTEX; HEMISPHERIC-SPECIALIZATION; PARAHIPPOCAMPAL CORTICES; COGNITIVE FUNCTIONS; BRAIN ACTIVATION; EPISODIC MEMORY; WORKING-MEMORY; RHESUS-MONKEYS; HIPPOCAMPUS;
Keywords:
PET; activation study; F-18-fluorodeoxyglucose; nonhuman primate; visual recognition memory; delayed matching-to-sample;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Baron, JC INSERM, U320, Ctr Cyceron, BP5229, F-14074 Caen, France INSERM BP5229 Caen France F-14074 BP5229, F-14074 Caen, France
Citazione:
X. Blaizot et al., "Mapping the visual recognition memory network with PET in the behaving baboon", J CEREBR B, 20(2), 2000, pp. 213-219

Abstract

By means of a novel F-18-fluoro-deoxyglucose PET method designed for cognitive activation imaging in the baboon, the large-scale neural network involved in visual recognition memory in the nonhuman primate was mapped for thefirst time. In this method, the tracer is injected in the awake, unanesthetized, and unrestrained baboon performing the memory task, and brain imaging is performed later under light anesthesia. Brain maps obtained during a computerized trial-unique delayed matching-to-sample task (lists of meaningless geometrical patterns and delay > 9 seconds) were statistically comparedpixel-by-pixel to maps obtained during a specially designed visuomotor control task. When displayed onto the baboon's own anatomic magnetic resonanceimages, foci of significant activation were distributed along the ventral occipitotemporal pathway, the inferomedial temporal lobe (especially the perirhinal cortex and posterior hippocampal region); and the orbitofrontal cortex, consistent with lesion, single-unit, and autoradiographic studies in monkeys, as well as with activation studies in healthy humans. Additional activated regions included the nucleus basalis of Meynert, the globus pallidus and the putamen. The results also document an unexpected left-sided advantage, suggesting hemispheric functional specialization for recognition of figural material in nonhuman primates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:58:57