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Titolo:
Issues in understanding childhood asthma
Autore:
Warner, JO; Pohunek, P; Marguet, C; Roche, WR; Clough, JB;
Indirizzi:
Univ Southampton, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD 6 6YD, Hants, England
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 105, anno: 2000,
parte:, 2 supplemento:, S
pagine: S473 - S476
SICI:
0091-6749(200002)105:2<S473:IIUCA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-FUNCTION; RISK FACTOR; CHILDREN; INFANTS; LIFE; ALLERGENS; AIRWAYS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Warner, JO Univ Southampton, Southampton Gen Hosp, Mailpoint 803,Tremona Rd, Southampton SO16 6YD, Hants, England Univ Southampton Mailpoint 803,Tremona Rd Southampton Hants England SO16 6YD
Citazione:
J.O. Warner et al., "Issues in understanding childhood asthma", J ALLERG CL, 105(2), 2000, pp. S473-S476

Abstract

Asthma and related allergic disorders in childhood have increased considerably in prevalence over the last few decades. During the same period of increasing morbidity from childhood asthma in the community, there have been dramatic advances in understanding of the basic immunopathologic features ofthe disease and consequently the development of a far more rational approach to its treatment. The immunopathologic condition of eosinophil-mediated airway inflammation is established very early in the evolution of asthma inchildhood. It may even antedate the onset of symptoms. The present state of the art dictates that early intervention with potent therapies cannot be justified on the basis of symptoms alone and may in any case have no influence on the natural history of the condition, This means that current cautious therapeutic guidelines should continue to be followed. However, with thedevelopment of more accurate markers predicting ongoing disease, it will be possible to evaluate a whole range of early interventions in the future. Much evidence, though indirect, points to the possibility that the only true prophylaxis that will affect the natural history of asthma will need to be commenced before clinical features are manifest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 15:15:10