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Titolo:
Central obesity, depression and the hypothalamo - pituitary - adrenal axisin men and postmenopausal women
Autore:
Katz, JR; Taylor, NF; Goodrick, S; Perry, L; Yudkin, JS; Coppack, SW;
Indirizzi:
UCLMS, Dept Med, London N19 3UA, England UCLMS London England N19 3UAUCLMS, Dept Med, London N19 3UA, England Univ London Kings Coll Hosp, Dept Clin Biochem, London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England Univ London St Bartholomews Hosp Med Coll, Dept Clin Biochem, London EC1A 7BE, England Univ London St Bartholomews Hosp Med Coll London England EC1A 7BE ngland
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 2, volume: 24, anno: 2000,
pagine: 246 - 251
SICI:
0307-0565(200002)24:2<246:CODATH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; BODY-FAT DISTRIBUTION; CORTISOL SECRETION; ABDOMINAL OBESITY; SEXUAL DIMORPHISM; STIMULATION; LEPTIN; STRESS; METABOLISM; RESPONSES;
Keywords:
CRH; corticotrophin; central obesity; obesity; leptin; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, JR Whittington Hosp, Dept Med, F Block,Archway Wing,Archway Rd, London N19 3UA, England Whittington Hosp F Block,Archway Wing,Archway Rd London England N19 3UA
Citazione:
J.R. Katz et al., "Central obesity, depression and the hypothalamo - pituitary - adrenal axisin men and postmenopausal women", INT J OBES, 24(2), 2000, pp. 246-251

Abstract

OBJECTIVE: We examined the relationship of adiposity to pituitary-adrenal responses to corticotrophin-releasing hormone (CRH) in men and postmenopausal women, controlling for the influence of depression. DESIGN: Studies of CRH responses, cortisol metabolite levels and depression scores in relation to adiposity in men and postmenopausal women. SUBJECTS: Thirteen men: age (median, interquartile range) 62 y (52-63), body mass index (BMI) 29.0 kg/m(2) (26.3-33.1), waist circumference (waist) 105 cm (97-111), waist:hip ratio (WHR) 1.03 (0.98-1.07), subscapular to triceps skinfold thickness ratio (STR) 2.0 (1.2-2.4), total body fat (TBF) 25.4kg (19.8-28.8); and eight women: age 54 y (53-62), BMI 30 kg/m(2) (23-41),waist 86 cm (79-117), WHR 0.94 (0.87-1.10), STR 1.0 (0.85-1.07), TBF 35.0 kg (18.7-48.8). MEASUREMENTS: A standard CRH test was conducted with additional basal samples taken for leptin and interleukin 6 (IL-6). Total urine cortisol metabolites (TCM) and the ratio of urinary cortisol:cortisone (Fm/Em) metabolites were measured. Depression scores were measured by the General Health Questionnaire (GHQ-30) and Hospital Anxiety and Depression Scale (HAD) questionnaire. All subjects completed an overnight dexamethasone suppression test. RESULTS: The basal to peak percentage increments (%inc.) in adrenocorticotrophic hormone (ACTH) and cortisol in men correlated directly with SIR (ACTH %inc. r = 0.70, P < 0.01; cortisol %inc. r = 0.55, P = 0.05); this relationship was independent of depression scores. In women, the ACTH area under incremental curve (AUIC) correlated negatively with STR (r = -0.81, P(0.05). In men, but not in women, there was a significant correlation between GHQ-30 score and ACTH AUIC (r = 0.62, P < 0.05) and cortisol AUIC (r = 0.72, P< 0.01). Depression scores were consistently and directly related to indices of obesity and central obesity. There were no significant relationships in either sex between urinary TCM or Fm/Em ratio and BMI, waist, WHR, TBF, STR or CRH responses. The urinary Fm/Em ratio was higher in men than in women (median 0.74 vs 0.66, P < 0.05). In men, but not in women, GHQ-30 scorescorrelated positively with urinary TCM (r = 0.57, P = 0.05) and HAD-depression scores were inversely related to the urine Fm/Em ratio (r = -0.65, P <0.05). All subjects suppressed normally with dexamethasone. CONCLUSIONS: Cortisol metabolite levels were increased in depression in men, but were not related to adiposity in either sex. We demonstrate that central obesity in men, but not postmenopausal women, is associated with an enhanced pituitary-adrenal response to CRH and that this relationship is independent of depression score.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:56:48