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Titolo:
Soluble human MHC class I molecules induce soluble Fas ligand secretion and trigger apoptosis in activated CD8(+) Fas (CD95)(+) T lymphocytes
Autore:
Puppo, F; Contini, P; Ghio, M; Brenci, S; Scudeletti, M; Filaci, G; Ferrone, S; Indiveri, F;
Indirizzi:
Univ Genoa, Dept Internal Med, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 , Dept Internal Med, I-16132 Genoa, Italy Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA Roswell Pk Canc Inst Buffalo NY USA 14263 Immunol, Buffalo, NY 14263 USA
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 2, volume: 12, anno: 2000,
pagine: 195 - 203
SICI:
0953-8178(200002)12:2<195:SHMCIM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SURFACE-ANTIGENS; MONOCLONAL-ANTIBODIES; HUMAN-SERUM; HLA ANTIGENS; MEDIATED CYTOTOXICITY; IMMUNE-RESPONSES; ALPHA-3 DOMAIN; HIV-INFECTION; COMPLEX; CD4;
Keywords:
HLA; immunomodulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Puppo, F Univ Genoa, Dept Internal Med, Viale Benedetto 15 6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto 15 6 Genoa Italy I-16132 Genoa, Italy
Citazione:
F. Puppo et al., "Soluble human MHC class I molecules induce soluble Fas ligand secretion and trigger apoptosis in activated CD8(+) Fas (CD95)(+) T lymphocytes", INT IMMUNOL, 12(2), 2000, pp. 195-203

Abstract

In the present study, we have evaluated the apoptotic effect of soluble human MHC class I (sHLA-I) antigens on CD8(+) T lymphocytes. sHLA-I antigens and beta(2)-microglobulin-free HLA class I heavy chains, isolated from serum, induced apoptosis on phytohemagglutinin-activated CD8(+) T lymphocytes in autologous and allogeneic combinations. The extent of CD8(+) T cell apoptosis depends on the degree of activation, time of incubation with sHLA-I antigens and amount of sHLA-I antigens added to the cultures. Apoptosis is induced by the interaction of Fas (CD95)(+) cells with soluble Fas ligand which is released following binding of sHLA-I antigens to CD8 molecules. Theseresults suggest that sHLA-I antigens may regulate immune responses by inducing apoptosis in activated CD8(+) T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:00:55