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Titolo:
IL-6 inhibits the proliferation of fibroblastic synovial cells from rheumatoid arthritis patients in the presence of soluble IL-6 receptor
Autore:
Nishimoto, N; Ito, A; Ono, M; Tagoh, H; Matsumoto, T; Tomita, T; Ochi, T; Yoshizaki, K;
Indirizzi:
Osaka Univ, Dept Med Sci 1, Sch Hlth & Sport Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ort Sci, Suita, Osaka 5650871, Japan Osaka Univ, Sch Med, Dept Orthoped, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 rthoped, Suita, Osaka 5650871, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 2, volume: 12, anno: 2000,
pagine: 187 - 193
SICI:
0953-8178(200002)12:2<187:IITPOF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; STIMULATORY FACTOR-II; FACTOR-ALPHA; MONOCLONAL-ANTIBODY; BREAST-CARCINOMA; TNF-ALPHA; INTERLEUKIN-6; SERUM; FLUID; GROWTH;
Keywords:
IL-6; rheumatoid arthritis; soluble IL-6 receptor; synovial cell; tumor necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshizaki, K Osaka Univ, Dept Med Sci 1, Sch Hlth & Sport Sci, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-1 Yamadaoka Suita Osaka Japan 5650871 871, Japan
Citazione:
N. Nishimoto et al., "IL-6 inhibits the proliferation of fibroblastic synovial cells from rheumatoid arthritis patients in the presence of soluble IL-6 receptor", INT IMMUNOL, 12(2), 2000, pp. 187-193

Abstract

IL-6 and tumor necrosis factor (TNF)-alpha have been proven to play an important role in the development of rheumatoid arthritis (RA), It is well known that TNF-alpha induces IL-6 production from synovial cells as well as their proliferation. The effect of IL-6 on synovial cells, however, is not clear. An in vitro study was performed to determine the effect of IL-6 on theproliferation of synovial cells. Fibroblastic synovial cells isolated fromthe synovial tissues of eight RA patients were employed after the third tosixth passages. IL-6 in the presence of soluble IL-6 receptor (sIL-6R) inhibited the proliferation of synovial cells in a dose-dependent manner in seven cases without increasing the number of necrotic or apoptotic cells, while TNF-alpha increased synovial cell proliferation in all cases. The inhibitory effect of IL-6 was observed only in the presence of sIL-6R although small amounts of IL-6R were detected in these cells by RT-PCR analysis. However, anti-IL-6R or anti-gp130 mAb treatment increased spontaneous growth of synovial cells in all eight cases, suggesting that endogenous IL-6 and a small amount of IL-6R expressed in synovial cells suppressed their growth without exogenous IL-6 or sIL-6R. In addition, the IL-6-sIL-6R complex reducedthe TNF-alpha-induced proliferation of synovial cells while TNF-alpha induced their IL-6 production. These data suggest that IL-6 may act as a negative feedback factor for TNF-alpha-induced synovial cell growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 21:30:39