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Titolo:
Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells
Autore:
Hoyne, GF; Le Roux, I; Corsin-Jimenez, M; Tan, K; Dunne, J; Forsyth, LMG; Dallman, MJ; Owen, MJ; Ish-Horowicz, D; Lamb, JR;
Indirizzi:
Univ Edinburgh, Sch Med, Resp Med Unit, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland Imperial Canc Res Fund, Dev Genet Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England Imperial Canc Res Fund, Lymphocyte Mol Biol Labs, London WC2A 3PX, EnglandImperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England Univ London Imperial Coll Sci Technol & Med, Dept Biol, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med London England SW7 2AZ gland
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 2, volume: 12, anno: 2000,
pagine: 177 - 185
SICI:
0953-8178(200002)12:2<177:SNSRTD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC CELLS; AUTOIMMUNE ENCEPHALOMYELITIS; TRANSPLANTATION TOLERANCE; DELTA-HOMOLOG; IN-VITRO; INHIBITION; EXPRESSION; PEPTIDE; RESPONSES; MICE;
Keywords:
antigen-presenting cells; Notch signalling; peripheral tolerance; regulatory T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hoyne, GF Univ Edinburgh, Sch Med, Resp Med Unit, Teviot Pl, Edinburgh EH89AG, Midlothian, Scotland Univ Edinburgh Teviot Pl Edinburgh Midlothian Scotland EH8 9AG d
Citazione:
G.F. Hoyne et al., "Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells", INT IMMUNOL, 12(2), 2000, pp. 177-185

Abstract

Signals derived from antigen-presenting cells (APC) influence the functional differentiation of CD4(+) T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor, may contribute to the differentiation of peripheral CD4(+) T cells into either helper or regulatory cells. Our findings demonstrate that antigen presented by murine APC overexpressing human Serrate1 induces naive peripheral CD4(+) T cells to become regulatory cells. These cells can inhibit primary and secondary immune responses, and transfer antigen-specific tolerance to recipient mice. Our results show that Notch signalling may help explain 'linked' suppression in peripheral tolerance, whereby tolerance induced to one epitope encompasses all epitopes on that antigen during the course of an immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:24:14