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Titolo:
Decreased production of local immunoglobulin a to Pneumocystis carinii in bronchoalveolar lavage fluid from human immunodeficiency virus-positive patients
Autore:
Jalil, A; Moja, P; Lambert, C; Perol, M; Cotte, L; Livrozet, JM; Boibieux, A; Vergnon, JM; Lucht, F; Tran, R; Contini, C; Genin, C;
Indirizzi:
Univ St Etienne, Fac Med, GIMAP, F-42023 St Etienne 2, France Univ St Etienne St Etienne France 2 GIMAP, F-42023 St Etienne 2, France Hop Nord, Dept Pneumol, St Etienne, France Hop Nord St Etienne FranceHop Nord, Dept Pneumol, St Etienne, France Hop Lyon, Dept Pneumol, Lyon, France Hop Lyon Lyon FranceHop Lyon, Dept Pneumol, Lyon, France Hop Lyon, Dept Gastroenterol, Lyon, France Hop Lyon Lyon FranceHop Lyon, Dept Gastroenterol, Lyon, France Hop Lyon, Dept Clin Immunol, Lyon, France Hop Lyon Lyon FranceHop Lyon, Dept Clin Immunol, Lyon, France Hop Lyon, Dept Infect Dis, Lyon, France Hop Lyon Lyon FranceHop Lyon, Dept Infect Dis, Lyon, France Univ Ferrara, Inst Infect & Resp Dis, I-44100 Ferrara, Italy Univ FerraraFerrara Italy I-44100 ct & Resp Dis, I-44100 Ferrara, Italy
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 3, volume: 68, anno: 2000,
pagine: 1054 - 1060
SICI:
0019-9567(200003)68:3<1054:DPOLIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE GLYCOPROTEIN; ANTIGENIC VARIATION; INFECTED PATIENTS; HIV-1 INFECTION; ANTIBODIES; LUNG; RESPONSES; PROTEINS; CELLS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Genin, C Univ St Etienne, Fac Med, GIMAP, 15 Rue A Pare, F-42023 St Etienne 2, France Univ St Etienne 15 Rue A Pare St Etienne France 2 enne 2, France
Citazione:
A. Jalil et al., "Decreased production of local immunoglobulin a to Pneumocystis carinii in bronchoalveolar lavage fluid from human immunodeficiency virus-positive patients", INFEC IMMUN, 68(3), 2000, pp. 1054-1060

Abstract

An enzyme-linked immunosorbent assay and a Western blot analysis were developed to study the antibody response to Pneumocystis carinii in serum and bronchoalveolar lavage fluid from 27 human immunodeficiency virus 27 (HIV)-infected patients with P. carinii pneumonia (Pcp), 32 patients without Pcp, and 51 HIV-negative controls. Urea was used for the correct dilution of epithelial lining fluid, and albumin was used to evaluate transudation from plasma for the assessment of local production of antibodies to P. carinii. Bycontrast with those of immunoglobulin G (IgG), IgA responses to P, cariniiwere increased in serum from HIV-positive patients compared to negative controls. Local production of antibodies to P, carinii, especially IgA, was decreased in patients with Pcp, In a study of 10 patients of each group, IgGand IgA responses to gp116 from P. carinii were lower in patients with Pcpthan in other groups. These results suggest that, in addition to alveolar macrophages, local antibodies may play a role in host defense against P. carinii.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:17:12