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Titolo:
Cytokines in Mycoplasma hyorhinis-induced arthritis in pigs bred selectively for high and low immune responses
Autore:
Reddy, NRJ; Wilkie, BN; Borgs, P; Mallard, BA;
Indirizzi:
Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 athobiol, Guelph, ON N1G 2W1, Canada
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 3, volume: 68, anno: 2000,
pagine: 1150 - 1155
SICI:
0019-9567(200003)68:3<1150:CIMHAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY-PRODUCTION; 2 LINES; MICE; RESPONSIVENESS; EXPRESSION; DISEASE; GAMMA; CELLS; ALPHA; IL-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wilkie, BN Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 uelph, ON N1G 2W1, Canada
Citazione:
N.R.J. Reddy et al., "Cytokines in Mycoplasma hyorhinis-induced arthritis in pigs bred selectively for high and low immune responses", INFEC IMMUN, 68(3), 2000, pp. 1150-1155

Abstract

Yorkshire pigs were bred selectively for high and low immune responses (H and L pigs, respectively) based on multiple antibody (Ab) and cell-mediatedimmune response traits. In a previous experiment, generation 4 (G4) pigs of each line were infected with Mycoplasma hyorhinis, High responders had a more rapid and higher Ab response and less polyserositis, but arthritis wasmore severe in H pigs than in L pigs, To test the hypothesis that line differences were attributable to differential expression of cytokines, M. hyorhinis infection was induced in pigs of G8, Arthritis was more severe clinically (P, less than or equal to 0.05) and postmortem (P, less than or equal to 0.001) when M. hyorhinis CFU were more numerous in synovial fluid (SF) of H pigs than of L pigs (P, less than or equal to 0.03). In H pigs but not L pigs, CFU and lesion scores were correlated positively. In H pigs, infection increased the frequency of expression of mRNAs for interleukin-8 (IL-8), IL-10, and tumor necrosis factor alpha (TNF-alpha) in mononuclear cells from synovial membranes (SM), In L pig, IL-1 alpha, IL-6, IL-10, and TNF-alpha mRNAs were increased in frequency of expression. The quantity of the cytokine message for IL-6 was increased in infected H pigs, For L pigs, infection increased the cytokine message for IL-1 alpha, IL-6, IL-10, and TNF-alpha. IL-6 in SM and gamma interferon (IFN-gamma) in SF were produced at a higher copy number in H pigs than in L pigs after infection. For H pigs, there were no positive rank correlations between lesion or CFU scores and cytokines. For L pigs, IL-1 alpha, IL-8, IL-10, and TNF-alpha in SM correlated with CFU, while IL-6, TNF-beta, and IFN-gamma in SF correlated with CFU, Lesion score in L pigs correlated with IL-1 alpha in SF, While these results indicate that H and L pigs differ in the cytokine response to M. hyorhinis infection, they do not confirm a characteristic cytokine response in association with the relative susceptibility to infection and arthritis observed in H pigs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:59:00