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Titolo:
Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome
Autore:
Carter, MG; Johns, MA; Zeng, XB; Zhou, L; Zink, MC; Mankowski, JL; Donovan, DM; Baylin, SB;
Indirizzi:
Johns Hopkins Med Inst, Ctr Oncol, Baltimore, MD 21231 USA Johns Hopkins Med Inst Baltimore MD USA 21231 ol, Baltimore, MD 21231 USA Johns Hopkins Univ, Sch Med, Grad Program Human Genet & Mol Biol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 l Biol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Grad Program Cellular & Mol Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ol Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Div Comparat Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 at Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 mmunol, Baltimore, MD 21205 USA NIA, Transgen & Knockout Facil, NIH, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 & Knockout Facil, NIH, Baltimore, MD 21224 USA
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 3, volume: 9, anno: 2000,
pagine: 413 - 419
SICI:
0964-6906(20000212)9:3<413:MDITCT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN INTERACTION MOTIF; HUMAN BREAST-CANCER; DNA HYPERMETHYLATION; DROSOPHILA METAMORPHOSIS; LUNG CANCERS; EXPRESSION; DELETION; 17P13.3; DOMAIN; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Baylin, SB Johns Hopkins Med Inst, Ctr Oncol, Baltimore, MD 21231 USA Johns Hopkins Med Inst Baltimore MD USA 21231 re, MD 21231 USA
Citazione:
M.G. Carter et al., "Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome", HUM MOL GEN, 9(3), 2000, pp. 413-419

Abstract

HIC1 is a candidate tumor suppressor gene which is frequently hypermethylated in human tumors, and its location within the Miller-Dieker syndrome's critical deletion region at chromosome 17p13.3 makes it a candidate gene forinvolvement in this gene deletion syndrome. To study the function of murine Hid in development, we have created Hic1-deficient mice. These animals die perinatally and exhibit varying combinations of gross developmental defects throughout the second half of development, including acrania, exencephaly, cleft palate, limb abnormalities and omphalocele. These findings demonstrate a role for Hid in the development of structures affected in the Miller-Dieker syndrome, and provide functional evidence to strengthen its candidacy as a gene involved in this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:42:00