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Titolo:
Final height, armspan, subischial leg length and body proportions in juvenile chronic arthritis - A long-term follow-up study
Autore:
Zak, M; Muller, J; Pedersen, FK;
Indirizzi:
Univ Copenhagen, Rigshosp, Clin Pediat 2, DK-2100 Copenhagen O, Denmark Univ Copenhagen Copenhagen Denmark O at 2, DK-2100 Copenhagen O, Denmark Univ Copenhagen, Rigshosp, Clin Growth & Reprod, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark
Titolo Testata:
HORMONE RESEARCH
fascicolo: 2, volume: 52, anno: 1999,
pagine: 80 - 85
SICI:
0301-0163(199908)52:2<80:FHASLL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GROWTH-HORMONE; RHEUMATOID-ARTHRITIS;
Keywords:
arthritis, juvenile rheumatoid; arthritis, juvenile chronic; growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Zak, M Univ Copenhagen, Rigshosp, Clin Pediat 2, Dep 4064,Blegdamsvej 9, DK-2100 Copenhagen O, Denmark Univ Copenhagen Dep 4064,Blegdamsvej 9 Copenhagen Denmark O enmark
Citazione:
M. Zak et al., "Final height, armspan, subischial leg length and body proportions in juvenile chronic arthritis - A long-term follow-up study", HORMONE RES, 52(2), 1999, pp. 80-85

Abstract

Objective: Assessment of growth disturbances in adults with a history of juvenile chronic arthritis (JCA). Material and Methods: Sixty-five subjects,52 premenopausal females and 13 males with a mean age (range) of 32.2 years (22.3-49.4) participated. Mean age at disease onset was 5.7 years (0.8-15.8) and mean disease duration was 12.4 years (0.4-32). The follow-up time ranged from 18.7 to 46.9 years with a mean of 26.4 years. For each participant standard deviation scores (z-scores) for final height, delta-height (thedifference between observed and expected height), armspan, subischial leg length and sitting height ratio, were calculated. Results: The study group as a whole did not exhibit linear growth impairment. The categorical distribution of heights differed significantly from a expected distribution in a healthy population (p < 0.001). A height z-score <-2 SD was present in 10.7% of the study group, of whom all had polyarticular course of JCA. Polyarticular and systemic course of JCA (versus pauciarticular) (p = 0.022), systemic steroid treatment (p = 0.006) and Steinbrocker functional class II-IV (vs. I) in 1979 (p = 0.043) were variables associated with reduced delta-height. In linear regression analyses, disease severity defining variables were statistically significant predictors of reduced final height and armspan.27% of the study subjects had significantly reduced arm span (p < 0.001). Subischial leg length and body proportions (sitting height ratio) were normal. Conclusion: Our findings suggest that functionally impaired polyarticular and systemic JCA patients treated with systemic steroids may be at an increased risk of developing reduced final height and armspan. Disease control achieved by an aggressive therapeutic approach, if possible with a minimal use of systemic steroids, may reduce growth impairment in JCA. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:42:36