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Titolo:
Septohippocampal pathway as a site for the memory-impairing effects of ethanol
Autore:
Givens, B; Williams, JM; Gill, TM;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 1, volume: 10, anno: 2000,
pagine: 111 - 121
SICI:
1050-9631(2000)10:1<111:SPAASF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SPATIAL WORKING-MEMORY; EVENT-RELATED POTENTIALS; MEDIAL SEPTAL AREA; SINGLE UNITS; THETA-RHYTHM; SAMPLE PERFORMANCE; HIPPOCAMPAL; RATS; ALCOHOL;
Keywords:
theta rhythm; hippocampus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Givens, B Ohio State Univ, Dept Psychol, 1885 Neil Ave, Columbus, OH 43210USA Ohio State Univ 1885 Neil Ave Columbus OH USA 43210 OH 43210 USA
Citazione:
B. Givens et al., "Septohippocampal pathway as a site for the memory-impairing effects of ethanol", HIPPOCAMPUS, 10(1), 2000, pp. 111-121

Abstract

Ethanol affects behavior by interacting with synaptic sites at many levelsof the nervous system. However, it targets most readily and at the lowest concentrations those sites mediating higher cognitive functions such as attention and memory. The memory-impairing effects of ethanol are thought to involve the hippocampus, a structure particularly vulnerable to the effects ethanol at low concentrations and early in the rising phase of the blood ethanol concentration curve. One of the early, low-dose: effects of ethanol is an interruption of the normal physiological regulation of the hippocampusby the ascending septohippocampal pathway originating in the medial septalarea (MSA). Ethanol enhances GABAergic transmission in the MSA, thereby reducing the regularity:and vigor with which rhythmically bursting neurons ofthe MSA drive the hippocampal theta rhythm. Disruption of septohippocampalactivity also has consequences on the response of the hippocampus to cortical inputs. Ethanol produces a loss of hippocampal responsivity that reduces the ability of the hippocampus to encode and retrieve relevant stimulus information necessary for accurate memory. This paper examines the behavioral and neural evidence for hippocampal vulnerability to ethanol and exploresthe hypothesis that these effects are due to ethanol disrupting septohippocampal modulation of the hippocampus, resulting in impairments of memory. Hippocampus 2000;10:111-121. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 03/04/20 alle ore 10:58:28