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Titolo:
Ischemia-reperfusion injury of liver and therapeutic intervention
Autore:
Marubayashi, S; Asahara, T; Dohi, K;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Surg 2, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 Surg 2, Hiroshima 7348551, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 16, anno: 2000,
pagine: 233 - 253
SICI:
1386-6346(200002)16:3<233:IIOLAT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; ENDOTHELIAL-CELL-ADHESION; TUMOR-NECROSIS-FACTOR; PERFUSED-RAT-LIVER; HEPATIC ISCHEMIA/REPERFUSION INJURY; INDUCED NEUTROPHIL CHEMOATTRACTANT; PLATELET-ACTIVATING-FACTOR; MURINE ENDOTOXIN-SHOCK; KUPFFER CELLS;
Keywords:
ischemia-reperfusion injury; free radical; neutrophil; Kupffer cells; adhesion molecules; nuclear factor-kB;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
164
Recensione:
Indirizzi per estratti:
Indirizzo: Marubayashi, S Hiroshima Univ, Sch Med, Dept Surg 2, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 Japan
Citazione:
S. Marubayashi et al., "Ischemia-reperfusion injury of liver and therapeutic intervention", HEPATOL RES, 16(3), 2000, pp. 233-253

Abstract

It is clinically and pathophysiologically important to elucidate the mechanism of cellular injury during hepatic ischemia and subsequent reperfusion. Ischemia-reperfusion injury is complex. Effective prevention strategies will require specific actions during the different phases of ischemia-reperfusion injury, but optimal conditions will only be achieved once the mechanisms of injury at the cellular and molecular levels are understood. It is, therefore, important to study the intracellular signal transduction pathway for its clinical application. This review represents recent advances of the mechanism of hepatic ischemia and reperfusion injury, with special reference to the free radical-mediated injury, the activation of Kupffer cells and neutrophils and the implications of NF-kB activation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:58:57