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Titolo:
Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes
Autore:
Nakajo, N; Yoshitome, S; Iwashita, J; Iida, M; Uto, K; Ueno, S; Okamoto, K; Sagata, N;
Indirizzi:
Kyushu Univ, Grad Sch Sci, Dept Biol, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 Sci, Dept Biol, Fukuoka 8128581, Japan
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 3, volume: 14, anno: 2000,
pagine: 328 - 338
SICI:
0890-9369(20000201)14:3<328:AOWETM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATURATION-PROMOTING FACTOR; M-PHASE; SCHIZOSACCHAROMYCES-POMBE; DNA-REPLICATION; MOLECULAR MECHANISMS; PHOSPHORYLATES CDC2; INHIBITORY KINASE; STARFISH OOCYTES; S-PHASE; MOS;
Keywords:
cell cycle; meiosis; Mos; S phase; Wee1; Xenopus oocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Sagata, N Kyushu Univ, Grad Sch Sci, Dept Biol, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 Biol, Fukuoka 8128581, Japan
Citazione:
N. Nakajo et al., "Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes", GENE DEV, 14(3), 2000, pp. 328-338

Abstract

Meiotic cells undergo two successive divisions without an intervening S phase. However, the mechanism of S-phase omission between the two meiotic divisions is largely unknown. Here we show that Wee1, a universal mitotic inhibitor, is absent in immature (but not mature) Xenopus oocytes, being down-regulated specifically during oogenesis; this down-regulation is most likelydue to a translational repression. Even the modest ectopic expression of Wee1 in immature (meiosis I) oocytes can induce interphase nucleus reformation and DNA replication just after meiosis I. Thus, the presence of Wee1 during meiosis I converts the meiotic cell cycle into a mitotic-like cell cycle having S phase. In contrast, Myt1, a Wee1-related kinase, is present and directly involved in G(2) arrest of immature oocytes, but its ectopic expression has little effect on the meiotic cell cycle. These results strongly indicate that the absence of Wee1 in meiosis I ensures the meiotic cell cycle in Xenopus oocytes. Based on these results and the data published previously in other organisms, we suggest that absence of Wee1 may be a well-conserved mechanism for omitting interphase or S phase between the two meiotic divisions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:15:23