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Titolo:
The macrophage - a novel system to deliver gene therapy to pathological hypoxia
Autore:
Griffiths, L; Binley, K; Iqball, S; Kan, O; Maxwell, P; Ratcliffe, P; Lewis, C; Harris, A; Kingsman, S; Naylor, S;
Indirizzi:
Oxford BioMedica UK Ltd, Medawar Ctr, Oxford OX4 4GA, England Oxford BioMedica UK Ltd Oxford England OX4 4GA , Oxford OX4 4GA, England Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England Univ Oxford Oxford England lcome Trust Ctr Human Genet, Oxford, England John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund, Med Oncol Lab, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Lab, Oxford OX3 9DU, England Univ Sheffield, Sch Med, Dept Pathol, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2RX S Yorkshire, England Univ Oxford, Dept Biochem, Retroviral Mol Biol Grp, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU Mol Biol Grp, Oxford OX1 3QU, England
Titolo Testata:
GENE THERAPY
fascicolo: 3, volume: 7, anno: 2000,
pagine: 255 - 262
SICI:
0969-7128(200002)7:3<255:TM-ANS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAS DOMAIN PROTEIN-1; STABLE TRANSDUCTION; IN-VIVO; TUMOR; CELLS; IMMUNOTHERAPY; ACTIVATION; EXPRESSION; RECEPTORS; ENHANCER;
Keywords:
macrophage; hypoxia; cytochrome P450; cyclophosphamide; gene delivery; adenovirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Naylor, S Oxford BioMedica UK Ltd, Medawar Ctr, Robert Robinson Ave,OxfordSci Pk, Oxford OX4 4GA, England Oxford BioMedica UK Ltd Robert Robinson Ave,Oxford Sci Pk Oxford England OX4 4GA
Citazione:
L. Griffiths et al., "The macrophage - a novel system to deliver gene therapy to pathological hypoxia", GENE THER, 7(3), 2000, pp. 255-262

Abstract

The use of activated macrophages in the treatment of cancer has been largely ineffectual. By 'arming' these cells with the ability to express a therapeutic gene we demonstrate significant advances in the efficacy of this approach. We have used a hypoxia-regulated adenoviral vector to transduce human macrophages with either a reporter or a therapeutic gene encoding human cytochrome P4502B6 (CYP2B6). infiltration of transduced macrophages into a tumour spheroid results in induction of gene expression. We demonstrate significant tumour cell killing only in the presence of cyclophosphamide via activation by P4502B6 and show that this can be further targeted to tumours through hypoxia regulated gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:39:57