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Titolo:
EUKARYOTIC TRANSCRIPTION FACTOR-DNA COMPLEXES
Autore:
PATIKOGLOU G; BURLEY SK;
Indirizzi:
ROCKEFELLER UNIV,LAB MOL BIOPHYS NEW YORK NY 10021 ROCKEFELLER UNIV,HOWARD HUGHES MED INST NEW YORK NY 10021
Titolo Testata:
Annual review of biophysics and biomolecular structure
, volume: 26, anno: 1997,
pagine: 289 - 325
SICI:
1056-8700(1997)26:<289:ETFC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; MAGNETIC-RESONANCE SPECTROSCOPY; NF-KAPPA-B; 3-DIMENSIONAL SOLUTION STRUCTURE; RESOLUTION REFINED STRUCTURE; REGION LEUCINE-ZIPPER; START SITE SELECTION; CO-CRYSTAL STRUCTURE; BOX-BINDING PROTEIN; MAJOR LATE PROMOTER;
Keywords:
EUKARYOTIC TRANSCRIPTION FACTOR; PROTEIN-DNA COMPLEX; TRANSCRIPTIONAL ACTIVATORS; TATA BOX-BINDING PROTEIN; YY1; INITIATOR ELEMENT; DNA-BINDING DOMAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
156
Recensione:
Indirizzi per estratti:
Citazione:
G. Patikoglou e S.K. Burley, "EUKARYOTIC TRANSCRIPTION FACTOR-DNA COMPLEXES", Annual review of biophysics and biomolecular structure, 26, 1997, pp. 289-325

Abstract

Eukaryotes have three distinct RNA polymerases that catalyze transcription of nuclear genes. RNA polymerase II is responsible for transcribing nuclear genes encoding the messenger RNAs and several small. nuclear RNAs. Like RNA polymerases I and III, polymerase II cannot recognize its target promoter directly and initiate transcription without accessory factors. Instead, this large multisubunit enzyme relies on general transcription factors and transcriptional activators and coactivators to regulate transcription from class II promoters. X-ray crystallography and nuclear magnetic resonance spectroscopy have been used to study complexes of general transcription factors and transcriptional activators with their specific DNA targets. This work has provided important structural insights into transcription initiation by polymerase IIand the more general problem of DNA sequence recognition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:56:13