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Titolo:
Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibre
Autore:
Ichinose, M; Takahashi, T; Sugiura, H; Endoh, N; Miura, M; Mashito, Y; Shirato, K;
Indirizzi:
Tohoku Univ, Sch Med, Dept Internal Med 1, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 2, volume: 15, anno: 2000,
pagine: 248 - 253
SICI:
0903-1936(200002)15:2<248:BAHAIR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; BRONCHIAL RESPONSIVENESS; BRONCHOALVEOLAR LAVAGE; ASTHMATIC SUBJECTS; TISSUE KALLIKREIN; INDUCED SPUTUM; LYMPHOCYTES-T; EOSINOPHILS; BIOPSIES; HYPERREACTIVITY;
Keywords:
asthma; bradykinin; eosinophil; nitric oxide; sputum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ichinose, M Tohoku Univ, Sch Med, Dept Internal Med 1, Aoba Ku, 1-1 SeiryoMachi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
M. Ichinose et al., "Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibre", EUR RESP J, 15(2), 2000, pp. 248-253

Abstract

Airway hyperresponsiveness (AHR), in which airway inflammation has been reported to be a key factor, is an important component of asthma, However theprecise role of inflammation in AHR is still unclear,In this report, airway inflammatory changes were assessed using hypertonicsaline-induced sputum examination and exhaled nitric oxide analysis, and the relation between AHR to methacholine, airway calibre forced expiratory volume in one second (FEV1) and airway inflammatory indices examined. Furthermore, the changes in these variables were also examined by means of 8 weeks' open uncontrolled inhaled steroid administration (800 mu g.beclomethasone.day(-1)),Asthmatic subjects had higher eosinophil counts and bradykinin concentration in induced sputum and higher exhaled NO levels, and showed AHR to methacholine, Baseline AHR significantly correlated with FEV1 but not with indices of inflammation in sputum or exhaled air. Steroid inhalation therapy was associated with a reduction in eosinophil and bradykinin concentration in sputum and KO levels in exhaled air and an improvement In FEV1 and AHR, The changes in FEV1 and AHR were significantly related to changes in markers insputum and exhaled air (p<0.01 for each),These results suggest that baseline airway hyperresponsiveness tan be predicted from the airway calibre but not from inflammatory parameters in sputum or exhaled air. In contrast, the reversible component of airway hyperresponsiveness appeared to be associated with the reduction in airway inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 05:45:03