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Titolo:
Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody
Autore:
Colman, PG; Steele, C; Couper, JJ; Beresford, SJ; Powell, T; Kewming, K; Pollard, A; Gellert, S; Tait, B; Honeyman, M; Harrison, LC;
Indirizzi:
Royal Melbourne Hosp, Dept Endocrinol & Diabet, Melbourne, Vic 3050, Australia Royal Melbourne Hosp Melbourne Vic Australia 3050 ne, Vic 3050, Australia Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Burnet Clin Res Unit, Melbourne, Vic 3050, Australia Royal Melbourne Hosp Melbourne Vic Australia 3050 ne, Vic 3050, Australia Univ Adelaide, Womens & Childrens Hosp, Adelaide, SA, Australia Univ Adelaide Adelaide SA Australia ldrens Hosp, Adelaide, SA, Australia Royal Melbourne Hosp, Dept Pathol, Melbourne, Vic 3050, Australia Royal Melbourne Hosp Melbourne Vic Australia 3050 ne, Vic 3050, Australia
Titolo Testata:
DIABETOLOGIA
fascicolo: 2, volume: 43, anno: 2000,
pagine: 203 - 209
SICI:
0012-186X(200002)43:2<203:IAIIWA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN AUTOANTIBODIES; CELL ANTIBODIES; YOUNG DAISY; PREDICTION; IDDM; MELLITUS; MICROASSAY; MARKERS; ASSAY; RISK;
Keywords:
pre-clinical Type I diabetes; infants; insulin autoantibodies; GAD antibodies; IA2 antibodies; HLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Colman, PG Royal Melbourne Hosp, Dept Endocrinol & Diabet, Melbourne, Vic 3050, Australia Royal Melbourne Hosp Melbourne Vic Australia 3050 0, Australia
Citazione:
P.G. Colman et al., "Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody", DIABETOLOG, 43(2), 2000, pp. 203-209

Abstract

Aims/hypothesis. To determine the sequence of development of islet autoantibodies and their relation to HLA genes in infants at risk for Type I diabetes followed from birth. Methods. We followed 357 (189 male, 168 female) infants, with a first degree relative with Type I diabetes for a mean of 3 years from birth. Human leukocyte antigen typing and assays for insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADAb) and tyrosine phosphatase IA2 (IA2Ab) antibodies were done on cord blood, and venous blood was sampled every 6 months for IAA, GADAb and IA2Ab. Results. We did not find any antibodies in 263 (73 %) infants; 50 (14 %) were positive for a single antibody once, 19 (5 %) for a single antibody more than once and 25 (7 %) for two or more antibodies. Of the latter, 10 (2.8% overall) were persistently positive; they had higher frequencies of HLA DR4 (p < 0.01) and HLA DR3, 4 (p < 0.05). Of the group persistently positive for two or more antibodies four infants developed diabetes. Insulin autoantibodies were the first ones to develop in 64 % of infants with two or more antibodies. Conclusion/interpretation. Infants with high risk HLA-DR alleles and multiple antibodies at high risk for diabetes were identified. A much larger group of infants had transient low level increases usually of a single antibody. Whereas transient low level positivity could be attributed to difficulties with assay technique and cut off levels for normality, the results overall support the phenomenon of transient 'self limited' islet autoimmunity inat risk infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:56:31